血管源性轻度认知障碍合并代谢综合征患者的认知障碍特点和中医证候特征

Cognitive impairment performance and TCM syndrome in the vascular mild cognitive impairment patients with metabolic syndrome

目的:研究血管源性轻度认知障碍合并代谢综合征患者的认知障碍特点和中医证候特征。方法:将血管源性轻度认知障碍患者分为代谢综合征组(54例)和非代谢综合征组(142例),采用蒙特利尔认知量表(MoCA)进行认知功能测评,制定中医证候观察表采集中医四诊信息。结果:代谢综合征组的MoCA总分、注意力、抽象能力明显低于非代谢综合征组,其余各项无统计学差异。代谢综合征组分数与MoCA的得分有一定的相关性,相关系数r=-0.17,P=0.04。代谢综合征组痰、血瘀最为多见,且明显高于非代谢综合征组(P<0.01),非代谢综合征组以阴虚、血虚最为多见。两组的病位均主要涉及肾、肝,其次为脾、心,两组间无显著性差异。结论:代谢综合征增加轻度认知障碍的患病风险。血管源性轻度认知障碍合并代谢综合征患者,在正气亏虚的基础上,多有痰湿瘀血停滞。

Objective： To investigate the cognitive impairment performance and TCM syndrome in the vascular mild cognitive impairment patients with metabolic syndrome.Methods： The vascular mild cognitive impairment patients were divided into group of patients with metabolic syndrome（54 cases） and group of patients without metabolic syndrome（142 cases）.Cognitive function were assessed using MoCA scale.Chinese medical information were collected.Results： Patients with metabolic syndrome had lower MoCA total score,attention and abstraction ability than patients without metabolic syndrome,but no significant difference were shown in the rest of the cognitive function fields.MoCA were correlated with the number of metabolic syndrome components（r=-0.17,P=0.04）.Phlegm,blood stasis were the most common TCM syndrome in the metabolic syndrome group,and significantly higher than the group without metabolic syndrome group（P0.01）.Yin deficiency and blood deficiency were the most common TCM syndrome in the group without metabolic syndrome.The main location of disease were both in kidney,liver,spleen,heart in both group.Conclusion： Metabolic syndrome increased the risk of mild cognitive impairment.Vascular mild cognitive impairment patients with metabolic syndrome usually had phlegm and blood stasis based on deficiency.