手性树枝状大分子催化剂的合成及其在不对称催化中的应用进展

Progress of chiral Dendrimer catalysts synthesis and their application in asymmetric catalysis

根据手性催化剂活性位点在树枝状大分子(Dendrimer)中位置的不同,综述了催化活性位点分别位于Dendrimer核心和外围以及聚合物固载化的手性Dendrimer催化剂的合成及其在不对称氢化、不对称氢转移、不对称Michael加成、硼烷对酮的不对称还原、不对称醇醛缩合反应、不对称Diels-Alder反应等不对称催化反应中的应用,重点论述了树枝状结构及代数对手性催化剂的活性、对映选择性及循环利用的影响,并对开发活性、选择性和稳定性更高的可回收手性Dendrimer催化剂前景进行展望。

According to the different locations of chiral catalytically active species in Dendrimer,the progress of core or periphery functionalized chiral Dendrimer catalysts and polymer-supported chiral dendrimer catalysts synthesis and their application in asymmetric hydrogenation,asymmetric transfer hydrogenation,asymmetric Michael addition,asymmetric borane reduction of ketones,asymmetric aldol reaction,asymmetric diels-alder reaction is reviewed,which emphasizes the Dendritic structure and generation effects on the activity,enantioselectivity and recycling of chiral Dendrimer catalysts.And also prospects the future of recyclable chiral Dendrimer catalysts with high activity,stability and selectivity.