ABCG2和CD44V6在大肠癌中的表达及临床意义

Expression of ABCG2 and CD44V6 in the Colorectal Cancer and Clinical Significance

目的探讨大肠癌中ABCG2和CD44V6表达及其临床意义。方法采用免疫组织化学方法,检测60例大肠癌及正常大肠黏膜组织中ABCG2和CD44V6表达情况。结果大肠癌组织中ABCG2阳性表达水平明显高于正常大肠黏膜组织(68.3%vs 0),两者比较差异有统计学意义,P<0.001。ABCG2表达与肿瘤分化、淋巴结转移和患者无瘤生存时间有关,P<0.05。60例正常大肠黏膜组织中未检测CD44V6阳性表达,60例大肠癌中CD44V6阳性表达38例(52.1%),两者比较差异有统计学意义,P<0.05。CD44V6表达与肿瘤淋巴结转移有关,P<0.05。结论 ABCG2和CD44V6表达异常与大肠癌发生发展有关。ABCG2可能是预测大肠癌预后的重要指标之一。

Objective To evaluate the expression of ABCG2 and CD44V6 in colorectal cancer and their clinical significances.Methods Inmmunohistochemistry method was used to analyze the expression of ABCG2 AND CD44V6 in the colorectal cancer and normal tissue.Results The expression of ABCG2 in colorectal cancer was significantly higher than that in normal tissue（P0.001）.The expression of ABCG2 was related to tumor differentiation,lymph node metastasis and survival time（P0.05）.No CD44V6 protein expression was observed in 60 normal tissues,but CD44V6 was expressed in 38 of 60 colorectal cancer tissues.The expression of CD44V6 was related to lymph node metastasis.Conclusion Our date indicates that positive expression of ABCG2B and CD44V6 were a mechanism of tumor and ABCG2 is associated with prognosis of colorectal cancer.