期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

树突状细胞与人免疫缺陷病毒1型感染 被引量：1

Dendritic Cells and Human Immunodeficiency Virus Type 1 Infection
下载PDF
导出
摘要 树突状细胞在人免疫缺陷病毒1型感染过程中发挥重要作用。一方面树突状细胞可以清除病毒,另一方面人免疫缺陷病毒1型感染也会造成树突状细胞数量的减少和功能的削弱,从而逃避免疫清除。研究树突状细胞与人免疫缺陷病毒1型之间的相互作用,对于基于树突状细胞的人免疫缺陷病毒疫苗研发具有重要意义。 Dendritic cells（DCs）play a significant role in the process of human immunodeficiency virus type 1（HIV-1）infection.On one hand,DCs can kill HIV-1;on the other hand,HIV-1 infection reduces the amount of DCs and weakens their functions,which allows HIV-1 to escape from immune clearance.Studies on the interaction between DCs and HIV-1 will contribute to the development of DC-based vaccines for HIV.
作者 傅涓涓 潘修成
机构地区 徐州医学院附属医院感染性疾病科
出处 《医学综述》 2012年第2期177-179,共3页 Medical Recapitulate
关键词 树突状细胞 人免疫缺陷病毒1型 疫苗 Dendritic cells Human immunodeficiency virus type 1 Vaccine
分类号 R512.91 [医药卫生—内科学]
  • 相关文献

参考文献31

  • 1Donaghy H,Gazzard B,Gotch F,et al.Dysfunction and infection of freshly isolated blood myeloid and plasmacytoid dendritic cells in patients infected with HIV-1[J].Blood,2003,101(11):4505-4511.
  • 2Donaghy H,Pozniak A,Gazzard B,et al.Loss of blood CD11c(+)myeloid and CD11c(-)plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load[J].Blood,2001,98(8):2574-2576.
  • 3Sabado RL,O′Brien M,Subedi A,et al.Evidence of dysregulation of dendritic cells in primary HIV infection[J].Blood,2010,116(19):3839-3852.
  • 4Meera S,Madhuri T,Manisha G,et al.Irreversible loss of pDCs by apoptosis during early HIV infection may be a critical determinant of immune dysfunction[J].Viral Immunol,2010,23(3):241-249.
  • 5Lehmann C,Lafferty M,Garzino-Demo A,et al.Plasmacytoid dendritic cells accumulate and secrete interferon alpha in lymph nodes of HIV-1 patients[J].PLoS One,2010,5(6):e11110.
  • 6Nascimbeni M,Perie L,Chorro L,et al.Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-alpha expression[J].Blood,2009,113(24):6112-6119.
  • 7Wu L,Kewal-Ramani VN.Dendritic-cell interactions with HIV:infection and viral dissemination[J].Nat Rev Immunol,2006,6(11):859-868.
  • 8Feldman S,Stein D,Amrute S,et al.Decreased interferon-alpha production in HIV-infected patients correlates with numerical and functional deficiencies in circulating type 2 dendritic cell precursors[J].Clin Immunol,2001,101(2):201-210.
  • 9Gompels M,Patterson S,Roberts MS,et al.Increase in dendritic cell numbers,their function and the proportion uninfected during AZT therapy[J].Clin Exp Immunol,1998,112(2):347-353.
  • 10Pacanowski J,Kahi S,Baillet M,et al.Reduced blood CD123+(lymphoid)and CD11c+(myeloid)dendritic cell numbers in primary HIV-1 infection[J].Blood,2001,98(10):3016-3021.

同被引文献15

引证文献1

医学综述
2012年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部