小儿气管内插管时舒芬太尼静注的ED_(50)与ED_(95)

The ED_(50) and ED_(95) of sufentanil in pediatric patients for endotracheal intubation undergoing general anesthesia induction

目的测定七氟醚全麻诱导时舒芬太尼为小儿提供满意气管内插管条件的ED50与ED95。方法选择2～8岁择期行气管内插管全麻患儿100例,ASAⅠ级,随机均分为五组,七氟醚诱导后分别给予不同剂量舒芬太尼0.1μg/kg(S1组)、0.2μg/kg(S2组)、0.3μg/kg(S3组)、0.4μg/kg(S4组)、0.5μg/kg(S5组)行气管内插管。同时记录插管前1min(T1)、插管即刻(T2)、插管后1min(T3)、3min(T4)、5min(T5)、10min(T6)BP、HR及Narcotrend麻醉深度数值变化。在Viby-Mogensen气管内插管条件评价法评价气管内插管条件基础上使用概率单位分析法计算舒芬太尼为小儿提供满意气管内插管的ED50及ED95。结果在七氟醚呼气末浓度3%,Viby-Mogensen气管内插管条件评价为"优秀"时,结合患儿气管内插管心血管反应阴性作为满意气管内插管条件,舒芬太尼为小儿提供满意气管内插管的ED50为0.305μg/kg[95%可信区间(CI)为0.239～0.354μg/kg],ED95为0.598μg/kg(95%CI为0.484～1.019μg/kg)。结论在七氟醚呼气末浓度3%时,小儿气管内插管舒芬太尼静注ED50与ED95分别为0.305μg/kg和0.598μg/kg。

Objective To determine the ED50 endotraeheal intubation under sevoflurane anesthesia. and ED95 of sufentanil in pediatric patients for Methods One hundred patients aged 2-8 years old with ASA I undergoing general anesthesia with endotracheal intubation were randomly allocated into five groups with 20 cases each. After sevoflurane induction, different doses of sufentanil were given in accordance with corresponding groups as 0.1/μg/kg （group S1 ）, 0. 2 μg/kg （group S2）, 0.3 μg/kg （group Sa ）, 0.4μg/kg group （S4）, 0.5 μg/kg （group S5 ）, respectively. Keep track of BP, HR, and the grade and index of Narcotrend at 1 min before intubation（T1 ）, on intuhation（T2 ）, 1 min（T3 ）, 3 min （T4）, 5 rain （T5）, 10 min （T6） after intubation. Meanwhile, Viby-Mogensen endotracheal intubation evaluation method was used to evaluate endotracheal intubation condition, and the probit analysis was performed to calculate the ED50 and ED95 of sufentanil to provide satisfying conditions for endotracheal intubation in children. Results By maintaining the end-tidal concentration of sevoflurane at 3%, and the Viby-Mogensen scales for endotracheal intuhation was ＂excellent＂, along with the negative cardiovascular responses during intubation, the EDs0 and ED95 of sufentanil to provide satisfying intubation conditions for children were 0. 305μg/kg （95% CI 0. 239-0. 354 μg/kg） and 0. 598 μg/kg （95% CI 0. 484-1. 019 μg/kg）, end-tidal concentration of sevoflurane at 30%, the intubation conditions for children are 0. 305μg/kg respectively. Conclusion When maintaining the ED50 and ED95 of sufentanil to provide satisfying and 0. 598 μg/kg, respectively.＇