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PTEN蛋白在喉鳞癌中表达的研究 被引量:1

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摘要 PTEN抑癌基因是迄今为止发现的第1个具有磷酸酶活性的抑癌基因,定位于人类染色体10q23,全长200kb。PTEN蛋白定位于细胞质,具有双特异性磷酸酶活性,在酪氨酸磷酸酶和丝氨酸/苏氨酸磷酸酶介导的信号传递过程中具有重要作用。PTEN基因异常表达与肿瘤的侵袭、转移和生长有关。本研究采用免疫组织化学技术对喉鳞状细胞癌中PTEN蛋白的表达情况进行研究,旨在探讨PTEN蛋白在喉鳞癌的发生、发展中的临床意义。
出处 《山西医药杂志(上半月)》 CAS 2012年第2期130-131,共2页 Shanxi Medical Journal
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参考文献11

  • 1孔维佳,主编.耳鼻咽喉头颈外科学.北京:人民卫生出版社,2006.75.
  • 2Hao XP, Willis JE, Pretlow TG, et al. Loss of fragile histidine triad expession in colorectal carcinomas and premalignant lesions. Cancer Res, 2000,60 : 18-21.
  • 3Li J, Yen C, Liaw D,et al. PTEN, a putive protein tyrosine phosphatase gene mutated in humun brain breast and prostate cencen. Science, 1997, 275 : 1943-1947.
  • 4Steck PA, Pershouse MA. Identification of a candidate tumor suppressor gene, MMAC1, at chromosome 10q23, 3 that is mutated in mutiple advanced cancer. Nature Genetics, 1997, 15:386-359.
  • 5Li DM, Sun H. Tepl encoded by a candidate tumor supressor locus, is a novel protein thyrosine phosphatase regulated by transforming growth factor β1. Cancer Res, 1997, 57: 2130-2136.
  • 6De Graffenried LA, Fulcher L, Friedriehs WE, et al. Reduced PTEN expression in breast cancer cells confers susceptibility to inhibitors of the PI3 kinase/Akt pathway. Ann Oncol ,2004,15 : 1510-1516.
  • 7Tunca B, Bekar A, Cecener G, et al. Impact of novel PTEN mutations in Turkish patients with glioblastoma multiforme. J Neuro Oncology, 2006,3:263-269.
  • 8孔德玲,王桂芳.抑癌基因PTEN在宫颈癌中的表达及意义[J].现代中西医结合杂志,2005,14(17):2240-2241. 被引量:8
  • 9Tokunaga E, Oki E, Kimura Y,et al. Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpres- sion enhances the Akt activity thus leading to a negative pro- gesterone receptor expression in breast carcinoma. Breast Cancer Res Treatt, 2006, 3: 249-257.
  • 10沈娜,陈鸿雁.抑癌基因PTEN与头颈部肿瘤关系的研究[J].重庆医科大学学报,2007,32(4):445-448. 被引量:2

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  • 1李慧娥,冷雪芹,苏秉忠.PTEN和p33/ING1在食管癌的发生及浸润转移中的作用[J].中国医疗前沿(学术版),2008,3(2):12-13. 被引量:1
  • 2黄军科,张向阳,罗亚桐,刘铭,刘勇.PTEN基因在膀胱移行细胞癌中的表达及意义[J].医学临床研究,2007,24(9):1488-1490. 被引量:6
  • 3Li J, Yen C, Liaw D, Podsypanina K, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 1997, 275(5308): 1943-1947.
  • 4Tamura M, Gu J, Tran H, et al. PTEN gene and integrin signaling in cancer. J Natl Cancer Inst, 1999, 91(21 ):1820-1828.
  • 5Alexiou GA, Voulgaris S. The role of the PTEN gene in malignant gliomas.Neurol Neurochir Pol, 2010, 44( 1 ):80-86.
  • 6Tokunaga E, Oki E, Kimura Y, Yamanaka T, et al. Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression en- hances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma. Breast Cancer Res Treat, 2007, 101 (3): 249-257.
  • 7Aveyard JS, Skilleter A, Habuchi T, et al. Somatic mutation of PTEN in bladder carcinoma. Br J Cancer, 1999, 80(5-6): 904-908.
  • 8Tanaka M, Koul D, Davies MA, et al. MMAC1/PTEN inhibits cell growth and induces chemosensitivity to doxorubicin in human bladder cancer cells. Oncogene, 2000, 19(47): 5406-5412.
  • 9张先云,李庆文,马松,王洪兵,承泽农.PTEN与P27^kipl在膀胱移行细胞癌中的表达及相关性研究[J].实用医学杂志,2008,24(21):3631-3633. 被引量:2
  • 10王永华,庄乾元,胡志全,兰儒竹,周四维.膀胱移行细胞癌组织中B7-H1和PTEN的表达及意义[J].山东医药,2009,49(18):20-22. 被引量:3

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