卵巢上皮癌组织中p-mTOR的表达及意义

Expression and clinical significance of p-mTOR in epithelial ovarian cancer

目的:探讨磷酸化的哺乳动物雷帕霉素靶蛋白(p-mTOR)在卵巢上皮癌组织中的表达和临床意义。方法:采用免疫组化方法检测154例卵巢上皮癌、25例良性上皮瘤和34例正常卵巢组织中p-mTOR蛋白表达情况,并分析其与卵巢上皮癌临床病理特征的关系。结果:p-mTOR在卵巢上皮癌组织阳性表达率为53.90%(83/154),在正常卵巢和良性卵巢上皮瘤组织中表达缺失。其中卵巢浆液性囊腺癌、黏液性囊腺癌、内膜样腺癌患者组织中的p-mTOR蛋白阳性表达率依次为54.78%、58.33%、40.00%。卵巢上皮癌Ⅰ～Ⅱ期和Ⅲ～Ⅳ期患者中p-mTOR蛋白阳性表达率分别为23.05%和56.03%,Ⅲ～Ⅳ期患者明显高于Ⅰ～Ⅱ期(P<0.05)。在卵巢上皮癌高、中分化和低分化患者组织中,p-mTOR蛋白阳性表达率分别为53.95%和53.85%(P>0.05)。结论:p-mTOR在卵巢上皮癌中的高表达与肿瘤性质及发生发展相关,可能成为预测卵巢癌发生发展的新肿瘤标记物和治疗的靶点。

Objective：To investigate the expression of phosphorylate-mammalian target of rapamycin,p-mTOR,in epithelial ovarian cancer and its clinical significance.Methods：The expression of p-mTOR was detected individually in the specimens of 154 epithelial ovarian cancer,25 benign ovarian epithelia tumour,34 normal ovarian tissues by immunohistochemistry.The correlation of p-mTOR expression to clinicopathologic feature of epithelial ovarian cancer was analyzed.Results：The positive rate of p-mTOR in epithelial ovarian cancer was 53.90%.No expression was detected in benign ovarian epithelia tumour and normal ovarian tissues.The positive rate of p-mTOR in serous,mutinous,and endometriod ovarian adenocarcinoma was 54.78%,58.33%,and 40% respectively（P0.05）.The positive rate of p-mTOR in Ⅰ/Ⅱ and Ⅲ/Ⅳ stage epithelial ovarian cancers tissues was 23.05% and 56.03% respectively（P0.05）.The positive rate of p-mTOR was 53.95% and 53.85% respectively in high-moderately and poorly-differentiated epithelial ovarian cancers tissues（P0.05）.Conclusion：The overexpression of p-mTOR is closely related to epithelial ovarian cancer initiation and progression.The p-mTOR may be served as a new tumor molecular marker and target for anticancer therapy.