结直肠癌肝转移手术治疗123例疗效分析

Effect of surgical treatment on colorectal cancer with liver metastasis an analysis of 123 patients

目的探讨影响结直肠癌肝转移手术治疗的预后因素。方法回顾性分析中国医学科学院肿瘤医院腹部外科2000年1月至2011年1月资料完整并行手术治疗的123例结直肠癌肝转移病人的临床资料。结果全组病人1,3,5年存活率分别为87.2%,35.6%及21.1%。单因素分析显示肿瘤大小、术前癌胚抗原(CEA)水平、是否R0切除是影响预后的因素(P<0.05)。COX多因素分析显示是否R0切除是影响预后的独立危险因素。结论手术切除是结直肠癌肝转移病人获得长期生存的最佳手段,综合治疗是病人达到R0切除、改善远期疗效的关键。

Objective To explore the prognostic risk factors for colorectal cancer patients with liver metastasis who received surgical treatment. Methods The clinieopathological characters of 123 eolorectal cancer with liver metastasis patients who received surgical treatment between January 2000 and January 2011 in Cancer Hospital of CAMS were analyzed retrospectively. Results In all patients, 1,3,5-year survival were 87.2%, 35.6% and 21.1% respectively. Univariate analysis showed size of liver tumor, level of preoperative CEA, R0 resection were risk factors for prognosis. Multivariate analysis showed that R0 resection was the only independent risk factor. Conclusion Surgical treatment is still the optimal modality for coloreeta] cancer with liver metastasis. R0 resection is the key point for the patients to get a better prognosis.