维生素D_3对自身免疫病的调节作用

Vitamin D_3 Regulation Function on Autoimmune Diseases

免疫细胞存在维生素D受体(VDR),维生素D3通过其体内代谢活性产物1,25-(OH)2D3与VDR结合发挥免疫调节作用。1,25-(OH)2D3除了直接作用于T细胞外,还通过多种机制调节抗原递呈细胞的表型和功能,尤其是树突状细胞。对12,5-(OH)2D3免疫调节机制的认识提示其在自身免疫性疾病的治疗中可广泛应用。近年来的研究表明1,2,5-(OH)2D3可通过多种机制调节1型糖尿病、多发性硬化症、系统性红斑狼疮等自身免疫病的发病。

Vitamin D receptor（VDR）express in almost all immune cells.1,25-dihydroxyvitamin D3,the active form of vitamin D,play a role in immune regulation through binding with VDR.In addition to direct effects on T cell activation,1,25-Dihydroxyvitamin D3 also modulates the phenotype and function of antigen-presenting cells and in particular of dendritic cells through multiple mechanisms.Recent advances in understanding 1,25-Dihydroxyvitamin D3 immunomodulatory mechanisms suggest a wider applicability in the treatment of autoimmune diseases,such as type 1 diabetes,multiple sclerosis,systemic lupus erythematosus and other autoimmune diseases by several mechanisms,as indicated in recent studies.