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GSK3-Wnt信号通路与糖尿病肾病的关系 被引量：2

The Relationship between GSK3-Wnt Signaling and Diabetic Nephropathy
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摘要 Wnt信号通路参与细胞的分化、增殖和凋亡,与诸多疾病密不可分。糖原合酶激酶3(GSK3)是生物体内诸多信号通路的参与者,是Wnt信号通路的上游作用物,对其起着关键作用。糖尿病肾病的发生和发展机制复杂,在分子生物学上需要许多信号通路的参与。现就GSK3-Wnt信号通路与糖尿病肾病的关系进行总结和讨论。 Wnt signaling takes part in cells′differentiation,proliferation,and apoptosis,and has close relationship with plenty of diseases;GSK3,which takes part in many important biologic signal paths,locates at the upstream of Wnt signaling,and is of essential role.The mechanism of diabetic nephropathy is complicated,it includes lots of signal paths.Here is to summarize the relationship between GSK3-Wnt signaling and diabetic nephropathy.
作者 唐杰 郝丽荣
机构地区 哈尔滨医科大学附属第一医院肾脏内科
出处 《医学综述》 2012年第3期421-423,共3页 Medical Recapitulate
关键词 WNT信号 糖原合酶激酶3 糖尿病肾病 Wnt signaling GSK3 Diabetic nephropathy
分类号 R587.1 [医药卫生—内分泌]
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参考文献26

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二级参考文献39

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医学综述
2012年 第3期

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