期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

GSK3-Wnt信号通路与糖尿病肾病的关系 被引量：2

The Relationship between GSK3-Wnt Signaling and Diabetic Nephropathy
下载PDF
导出
摘要 Wnt信号通路参与细胞的分化、增殖和凋亡,与诸多疾病密不可分。糖原合酶激酶3(GSK3)是生物体内诸多信号通路的参与者,是Wnt信号通路的上游作用物,对其起着关键作用。糖尿病肾病的发生和发展机制复杂,在分子生物学上需要许多信号通路的参与。现就GSK3-Wnt信号通路与糖尿病肾病的关系进行总结和讨论。 Wnt signaling takes part in cells′differentiation,proliferation,and apoptosis,and has close relationship with plenty of diseases;GSK3,which takes part in many important biologic signal paths,locates at the upstream of Wnt signaling,and is of essential role.The mechanism of diabetic nephropathy is complicated,it includes lots of signal paths.Here is to summarize the relationship between GSK3-Wnt signaling and diabetic nephropathy.
作者 唐杰 郝丽荣
机构地区 哈尔滨医科大学附属第一医院肾脏内科
出处 《医学综述》 2012年第3期421-423,共3页 Medical Recapitulate
关键词 WNT信号 糖原合酶激酶3 糖尿病肾病 Wnt signaling GSK3 Diabetic nephropathy
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献26

  • 1Maiese K,Li F,Chong ZZ.The Wnt signaling pathway:aging gracefully as a protectionist[J].Pharmacol Ther,2008,118(1):58-81.
  • 2Li F,Chong ZZ,Maiese K.Winding through the WNT pathway during cellular development and demise[J].Histol Histopathol,2006,21(1):103-124.
  • 3Huang H,He X.Wnt/beta-catenin signaling:new(and old)players and new insights[J].Curr Opin Cell Biol,2008,20(2):119-125.
  • 4Mac Donald BT,Tamai K,He X.Wnt/beta-catenin signaling:components,mechanisms,and diseases[J].Dev Cell,2009,17(1):9-26.
  • 5Cadigan KM,Liu YI.Wnt signaling:complexity at the surface[J].J Cell Sci,2006,119(Pt 3):395-402.
  • 6Rayasam GV,Tulasi VK,Sodhi R,et al.Glycogen synthase kinase 3:more than a namesake[J].Br J Pharmacol,2009,156(6):885-898.
  • 7Wu D,Pan W.GSK3:a multifaceted kinase in Wnt signaling[J].Trends Biochem Sci,2010,35(3):161-168.
  • 8Xu C,Kim NG,Gumbiner BM.Regulation of protein stability by GSK3 mediated phosphorylation[J].Cell Cycle,2009,8(24):4032-4039.
  • 9Wagman AS,Johnson KW,Bussiere DE.Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes[J].Curr Pharm Des,2004,10(10):1105-1137.
  • 10Patel S,Doble B,Woodgett JR.Glycogen synthase kinase-3 in insulin and Wnt signalling:a double-edged sword[J].Biochem Soc Trans,2004,32(Pt 5):803-808.

二级参考文献39

  • 1Jia WP,Pang C,Chert L,et al.Epidemiological characteristics of diabetes mellitus and impaired glucose regulation in a Chinese adult population:the Shahghai Diabetes Studies,a cross-sectional 3-year follow-up study in Shanghai urban communities.Diabetologia,2007,50(2):286-292.
  • 2Kikkawa R,Koya D,Haneda M.Progression of diabetic nephropathy.Am J Kidney Dis,2003,41(3 Suupl 1):19-21.
  • 3Brito P,Fioretto P,Drummund K,et al.Proximal tubular basement membrane width in insulin-dependent diabetes mellitus.Kidney Int,1998,53(3):754-761.
  • 4Lane PH,Steffes MW,Fioretto P,et al.Renal interstitial expansion in insulin-dependent diabetes mellitus.Kidney Int,1993,43(3):661-667.
  • 5Najafian B,Crosson JT,Kim Y,et al.Glomerulotubular junction abnormalities are,associatod with proteinuria in type l diabetes.J Am Soc Nephrol,2006,17(4 Suppl 2):S53-60.
  • 6Kim Y,Kleppel MM,Butkowski R,et al.Differential expression of basement membrane collagen chains in diabetic nephropathy.Am J Pathol,1991,138(2):413-420.
  • 7Φsterby R.Early phases in the development of diabetic glomemlopathy.Acta Med Scand,1974,574(Suppl):3-82.
  • 8Mac-Moune Lai F,Szeto CC,Choi PC,et al.Isolate diffuse thickening of glomemlar capillary basement membrane:A renal lesion in prediabetes?Mod Pathol,2004,17(12):1506-1512.
  • 9Katz A,Caramori ML,Sisson-Ross S,et al.An increase in the cell component of the cortical interstitium antedates interstitial fibrosis in type 1 diabetic patients.Kidney Int,2002,61(6):2058-2066.
  • 10Fioretto P,Steffes MW,Mauer M.Glomerular structure in nonproteinuric IDDM patients with various levels of albuminuria.Diabetes,1994,43(11):1358-1364.

共引文献91

同被引文献14

引证文献2

二级引证文献2

医学综述
2012年 第3期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部