不同温度灸法的退热作用与体温调节中枢温度敏感神经元活动的关系

Antipyretic effect of moxibustion at different temperatures and its relationship with the activity of temperature sensitive neurons in thermotaxic center

目的:探索灸法退热效应的中枢机制及其与穴位感受系统的关系,为"热证可灸"提供科学依据。方法:选用新西兰兔18只,分为A组(静脉注射内毒素造模)、B组(注射内毒素后行40℃灸)、C组(注射内毒素后行48℃灸),每组6只。实验在动物肌肉松弛、行人工呼吸条件下进行。采用聚光灸恒温刺激"至阳"穴,以视前区-下丘脑前部热敏神经元放电为指标,观察3组处理对热敏神经元放电的影响。结果与结论:灸法对热原抑制体温调节中枢热敏神经元活动有显著的拮抗作用,因而取得退热的疗效,灸法的这种有效作用是通过刺激穴位的多觉型感受器产生的。

Objective To discover the central mechanisms of antipyretic effect of moxibustion and its relationship with the acupoint sensor so as to provide the scientific evidence for ＂the treatment of heat syndrome with moxibustion＂.Methods Eighteen New Zealand Rabbits were randomly assigned into three groups,named group A（modeling with intravenous injection of Endotoxin）,group B（moxibustion at 40℃ after Endotoxin injection） and group C（moxibustion at 48℃ after Endotoxin injection）,6 rabbits in each one.The experiment was undergoing in the condition of muscular relaxation and artificial respiration for the animals.The spotlight moxibustion at constant temperature was applied to ＂Zhiyang＂（GV 9）.The discharge of heat sensitive neurons（HSNs） at the preoptic region and anterior hypothalamus（POAH） was taken as the index.The impacts of the treatment on HSNs were observed in each group.Results and Conclusion Moxibustion had significant antagonism to the pyrogen on its inhibition to the activity of HSNs in the thermotaxic center.As a result,the antipyretic effect was obtained.It is concluded that the effective result of moxibustion is achieved by stimulating polymodal receptors of acupoints.