辛伐他汀对肥胖伴高脂血症患者炎症状态及氧化应激水平的影响

Effect of Simvastatin on Inflammation and Oxidative Stress in Obese Patients with Hypercholesterolemia

目的:观察辛伐他汀对肥胖伴高脂血症患者炎症状态及氧化应激水平的影响。方法:选择我院39例肥胖伴高脂血症的患者为试验组,服用辛伐他汀8周;并选择20例健康志愿者设为健康对照组,不作任何干预。所有研究对象在对照组服药前后检测血脂、血清C反应蛋白(CRP)、丙二醛(MDA)、过氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)。结果:治疗前与健康对照组比较,试验组患者血浆中炎症指标血浆CRP水平明显升高,氧化应激指标中MDA明显升高,SOD水平、GSH-Px活性明显降低,差异均有统计学意义(P<0.05)。服用辛伐他汀8周后,试验组患者较治疗前血清CRP、MDA明显降低,SOD水平、GSH-Px活性明显回升,差异亦有统计学意义(P<0.05)。结论:辛伐他汀可通过抗炎和抗氧化应激机制对肥胖伴高脂血症患者起到保护作用。

OBJECTIVE：To investigate the effect of simvastatin on inflammation and oxidative stress in obese patients with hypercholesterolemia.METHODS：The study included 39 obese patients with hypercholesterolemia receiving simvastatin for 8 weeks and 20 healthy volunteers as healthy control group without any intervention.Before and after medicayion,we measured the blood lipid,CRP,MDA,SOD and GSH-Px.RESULTS：The levels of CRP and MDA were remarkable increased and MDA,SOD,GSH-Px were significant decreased in obese patients with hypercholesterolemia（P0.05）.After taking the drugs,the levels of CRP and MDA were remarkably lowered and SOD and GSH-Px were significantly highered（P0.05）.CONCLUSIONS：Simvastatin can protect the obese patients with hypercholesterolemia from mechanism of inflammation and oxidative stress.