维拉佐酮合成路线图解
被引量:1
维拉佐酮合成路线图解
摘要
维拉佐酮(vilazodone,1)化学名为1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰基苯并呋喃-5-基)哌嗪,其盐酸盐的商品名为Viibryd,是由美国Trovis Pharmaceuticals LLC公司开发的一种具有双重作用的选择性5-羟色胺再摄取抑制剂和5-HT1A受体部分激动剂。
出处
《中国药物化学杂志》
CAS
CSCD
2012年第1期74-75,81,共3页
Chinese Journal of Medicinal Chemistry
参考文献5
-
1王来海,张瑞岭,李焕芬.新型抗抑郁药维拉唑酮的药理与临床评价[J].中国新药杂志,2011,20(18):1729-1731. 被引量:8
-
2BOETTCHER H, SEYFRIED C, BARTOSZYK G, et al. Preparation of (indolylalkyl)piperidines and -piperazines as drugs: DE,4333254 [ P ]. 1995 - 04 - 06.
-
3HEINRICH T, BOETFCHER H. A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone[ J]. Bioorg Med Chem Lett, 2004,14(10) .2681 -2684.
-
4HEINRICH T, BOETFCHER H, GERICKE R, et al. Synthesis and structure-activity relationship in a class of indolebutylpiperazines as dual 5-HT1A receptor agonists and serotonin reuptake inhibitors [ J ]. J Med Chem,2004,47(19) :4684 -4692.
-
5BATHE A. Method for the production of 5- E 4- [ 4- ( 5- cyano-3-indolyl ) butyl ] -1 -piperazinyl ] benzofuran-2- c arboxamide: WO,2006114202 [ P ]. 2006 - 11 - 02.
二级参考文献9
-
1KHAN A. Vilazodone, a novel dual-acting serotonergic antidepres- sant for managing major depression [ J ]. Expert Opin lnvestig Drugs, 2009,18 ( 11 ) : 1753 - 1764.
-
2HOWLAND RH. Vilazodone: another novel atypical antidepres- sant drug[ J ] . J Psychosoc Nurs Ment Health Serv , 2011,49 ( 3 ) : 19 -22.
-
3DAWSON LA, WATSON JM. Vilazodone: a 5-HT1A receptor ago- nist/serotonin transporter inhibitor for the treatment of affective disorders [ J ]. CNS Neurosci Ther ,2009 ,15 (2) : 107 - 117.
-
4DE PAULIS T. Drug evaluation: vilazodone- a combined SSRI and 5-HT1A partial agonist for the treatment of depression [ J]. Drugs,2007,10 ( 3 ) : 193 - 201.
-
5ROBERTS C, HAGAN JJ, BARTOSZYK GD, et al. Effect of vilazodonc on 5-HT efflux and re-uptake in the guinea-pig dorsal raphc nucleus [ J ]. Eur J Pharmacol,2005,517 ( 1 - 2 ) : 59 - 63.
-
6HUGHES ZA, STARR KR, LANGMEAD C J, et al. Neurochemi- cal evaluation of the novel 5-HT1A receptor partial agonist/seroto- nin reuptake inhibitor, vilazodone [ J ]. Eur J Pharmacol, 2005, 510(1 -2) :49 -57.
-
7Vilazodone [ EB/OL ]. [ 2011 - 05 - 20 ]. http ://www. accessda-ta. fda. gov/drugsatfda docs/label/20! 1/022567s0001b1. pdf.
-
8RICKELS K, ATHANASIOU M, ROBINSON DS,et al. Evidenee for efficacy and tolerability of vilazodone in the treatment of major depressive disorder: a randomized, double-blind, placebo-con- trolled trial[ J ]. J Clin Psychiatry, 2009,70 ( 3 ) : 326 - 333.
-
9KHAN A, CUTLER AJ, KAJDASZ DK, et al. A randomized, double-blind, plaeebo-controlled, 8-week study of vilazodone, a serotonergic agent for the treatment of major depressive disorder [J]. J Clin Psyehiatry,2011,72(4):441 -447.
共引文献7
-
1王启发,程青芳,陈娜,郑国闯,帅美.盐酸维拉唑酮的合成[J].中国医药工业杂志,2013,44(1):3-5. 被引量:1
-
2程青芳,王启发,邱峰,唐建平,廖云鹏.盐酸维拉唑酮的合成方法改进[J].中国新药杂志,2013,22(2):226-229. 被引量:2
-
3郭智,王丹,刘婷立,薛烨,宋冬梅.盐酸维拉佐酮的药理作用和临床研究[J].中南药学,2013,11(3):219-221. 被引量:3
-
4张科技.抗焦虑和抗抑郁药物在烧伤康复治疗中的应用[J].中国医药指南,2013,11(25):445-446.
-
5王志龙,康江鹏,潘毅,陈蔚,王立敏.盐酸维拉佐酮的合成工艺研究[J].现代药物与临床,2015,30(7):753-756. 被引量:1
-
6陈瑞,韩晗,徐芸.维拉佐酮的合成[J].广州化工,2016,44(5):114-115.
-
7康江鹏,潘毅,陈蔚,陶勇.盐酸维拉佐酮的合成工艺改进研究[J].现代药物与临床,2017,32(3):361-364. 被引量:1
同被引文献8
-
1Boettcher H,Seyfried C,Greiner H. Piperazinylbenzodioxane derivatives [P]. US: 5242925,1993-09-07.
-
2Bottcher H,Seyfried C,Bartoszyk G,et al. Piperidines and piperazines [P]. US: 5532241,1996-07-02.
-
3上海医药工业研究院. 4-(5-氰基-1H-吲哚-3-基)丁基取 代磺酸类化合物及其应用 [P].中国: 102267932A,2011-12-07.
-
4上海医药工业研究院. 维拉佐酮或其盐酸盐的制备方 法 [P].中国: 102267985A,2011-12-7.
-
5上海开义医药化工有限公司. 3-(4-氯丁酰基)-1H-吲哚-5- 甲氰的制备方法 [P].中国: 102249979A,2011-11-23.
-
6王永福,王成港,王春龙.成人重度抑郁症治疗药物维拉佐酮(Vilazodone)片[J].药物评价研究,2011,34(4):311-314. 被引量:3
-
7王来海,张瑞岭,李焕芬.新型抗抑郁药维拉唑酮的药理与临床评价[J].中国新药杂志,2011,20(18):1729-1731. 被引量:8
-
8王启发,程青芳,陈娜,郑国闯,帅美.盐酸维拉唑酮的合成[J].中国医药工业杂志,2013,44(1):3-5. 被引量:1
-
1李赛,宫平.维拉佐酮盐酸盐[J].中国药物化学杂志,2011,21(4):329-329. 被引量:2
-
2黄洪勇,职晓燕,王传升,杨广声,师天元.反相高效液相色谱法测定人体血浆中维拉佐酮的含量[J].中国医院药学杂志,2017,37(7):596-598.
-
3王志龙,康江鹏,潘毅,陈蔚,王立敏.盐酸维拉佐酮的合成工艺研究[J].现代药物与临床,2015,30(7):753-756. 被引量:1
-
4国外新批准上市的药物新制剂新剂型(159)[J].中国制药信息,2011,27(4):16-18.
-
5陈瑞,韩晗,徐芸.维拉佐酮的合成[J].广州化工,2016,44(5):114-115.
-
6张新花,宗慎平,储益平,李红琴,郭勇勤.醋酸甲羟孕酮原料的粒径对溶出度的影响[J].药学与临床研究,1998,13(4):15-17. 被引量:2
-
7田野,童仲夏,梁振,焦恩强,郭春.维拉佐酮的合成工艺研究[J].中国药物化学杂志,2015,25(2):118-121. 被引量:3
-
8康江鹏,潘毅,陈蔚,陶勇.盐酸维拉佐酮的合成工艺改进研究[J].现代药物与临床,2017,32(3):361-364. 被引量:1
-
9黄胜炎(摘译).国外新批准上市的药物新制剂新剂型(166)[J].中国制药信息,2011,27(11):20-23.
-
10郭智,王丹,刘婷立,薛烨,宋冬梅.盐酸维拉佐酮的药理作用和临床研究[J].中南药学,2013,11(3):219-221. 被引量:3