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维拉佐酮合成路线图解 被引量:1

维拉佐酮合成路线图解
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摘要 维拉佐酮(vilazodone,1)化学名为1-[4-(5-氰基吲哚-3-基)丁基]-4-(2-氨甲酰基苯并呋喃-5-基)哌嗪,其盐酸盐的商品名为Viibryd,是由美国Trovis Pharmaceuticals LLC公司开发的一种具有双重作用的选择性5-羟色胺再摄取抑制剂和5-HT1A受体部分激动剂。
出处 《中国药物化学杂志》 CAS CSCD 2012年第1期74-75,81,共3页 Chinese Journal of Medicinal Chemistry
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参考文献5

  • 1王来海,张瑞岭,李焕芬.新型抗抑郁药维拉唑酮的药理与临床评价[J].中国新药杂志,2011,20(18):1729-1731. 被引量:8
  • 2BOETTCHER H, SEYFRIED C, BARTOSZYK G, et al. Preparation of (indolylalkyl)piperidines and -piperazines as drugs: DE,4333254 [ P ]. 1995 - 04 - 06.
  • 3HEINRICH T, BOETFCHER H. A new synthesis of indole 5-carboxylic acids and 6-hydroxy-indole-5-carboxylic acids in the preparation of an o-hydroxylated metabolite of vilazodone[ J]. Bioorg Med Chem Lett, 2004,14(10) .2681 -2684.
  • 4HEINRICH T, BOETFCHER H, GERICKE R, et al. Synthesis and structure-activity relationship in a class of indolebutylpiperazines as dual 5-HT1A receptor agonists and serotonin reuptake inhibitors [ J ]. J Med Chem,2004,47(19) :4684 -4692.
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二级参考文献9

  • 1KHAN A. Vilazodone, a novel dual-acting serotonergic antidepres- sant for managing major depression [ J ]. Expert Opin lnvestig Drugs, 2009,18 ( 11 ) : 1753 - 1764.
  • 2HOWLAND RH. Vilazodone: another novel atypical antidepres- sant drug[ J ] . J Psychosoc Nurs Ment Health Serv , 2011,49 ( 3 ) : 19 -22.
  • 3DAWSON LA, WATSON JM. Vilazodone: a 5-HT1A receptor ago- nist/serotonin transporter inhibitor for the treatment of affective disorders [ J ]. CNS Neurosci Ther ,2009 ,15 (2) : 107 - 117.
  • 4DE PAULIS T. Drug evaluation: vilazodone- a combined SSRI and 5-HT1A partial agonist for the treatment of depression [ J]. Drugs,2007,10 ( 3 ) : 193 - 201.
  • 5ROBERTS C, HAGAN JJ, BARTOSZYK GD, et al. Effect of vilazodonc on 5-HT efflux and re-uptake in the guinea-pig dorsal raphc nucleus [ J ]. Eur J Pharmacol,2005,517 ( 1 - 2 ) : 59 - 63.
  • 6HUGHES ZA, STARR KR, LANGMEAD C J, et al. Neurochemi- cal evaluation of the novel 5-HT1A receptor partial agonist/seroto- nin reuptake inhibitor, vilazodone [ J ]. Eur J Pharmacol, 2005, 510(1 -2) :49 -57.
  • 7Vilazodone [ EB/OL ]. [ 2011 - 05 - 20 ]. http ://www. accessda-ta. fda. gov/drugsatfda docs/label/20! 1/022567s0001b1. pdf.
  • 8RICKELS K, ATHANASIOU M, ROBINSON DS,et al. Evidenee for efficacy and tolerability of vilazodone in the treatment of major depressive disorder: a randomized, double-blind, placebo-con- trolled trial[ J ]. J Clin Psychiatry, 2009,70 ( 3 ) : 326 - 333.
  • 9KHAN A, CUTLER AJ, KAJDASZ DK, et al. A randomized, double-blind, plaeebo-controlled, 8-week study of vilazodone, a serotonergic agent for the treatment of major depressive disorder [J]. J Clin Psyehiatry,2011,72(4):441 -447.

共引文献7

同被引文献8

  • 1Boettcher H,Seyfried C,Greiner H. Piperazinylbenzodioxane derivatives [P]. US: 5242925,1993-09-07.
  • 2Bottcher H,Seyfried C,Bartoszyk G,et al. Piperidines and piperazines [P]. US: 5532241,1996-07-02.
  • 3上海医药工业研究院. 4-(5-氰基-1H-吲哚-3-基)丁基取 代磺酸类化合物及其应用 [P].中国: 102267932A,2011-12-07.
  • 4上海医药工业研究院. 维拉佐酮或其盐酸盐的制备方 法 [P].中国: 102267985A,2011-12-7.
  • 5上海开义医药化工有限公司. 3-(4-氯丁酰基)-1H-吲哚-5- 甲氰的制备方法 [P].中国: 102249979A,2011-11-23.
  • 6王永福,王成港,王春龙.成人重度抑郁症治疗药物维拉佐酮(Vilazodone)片[J].药物评价研究,2011,34(4):311-314. 被引量:3
  • 7王来海,张瑞岭,李焕芬.新型抗抑郁药维拉唑酮的药理与临床评价[J].中国新药杂志,2011,20(18):1729-1731. 被引量:8
  • 8王启发,程青芳,陈娜,郑国闯,帅美.盐酸维拉唑酮的合成[J].中国医药工业杂志,2013,44(1):3-5. 被引量:1

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