IgA肾病患者的肾脏病理学特征

Pathological characteristics of 407 cases with IgA nephropathy

目的分析IgA肾病的肾脏病理特点。方法回顾性分析经皮肾穿刺确诊为IgA肾病的407例患者的病理资料。结果 IgA肾病Lee氏分级以Ⅱ级、Ⅲ级为主。病理表现上,局灶节段病变占38.04%,系膜增生型占32.24%,轻微病变型占24.28%。Lee氏分级与免疫荧光沉积强度相关(Z=17.187,P<0.05)。结论 IgA肾病患者的病理表现多样。Lee分级与免疫荧光强度存在一定的相关性。

Objective To analyze the pathological characteristics of IgA nephropathy（IgAN）.Methods A positive diagnosis of primary IgAN was made after successive native renal biopsies in 407 in-patients.The pathological features of these patients were analyzed retrospectively.ResultsLee′s pathological grades of Ⅱ and Ⅲ were the most common types.Pathologically,focal segmental glomerulonephritis accounted for 38.04%,mesangial proliferative glomerulonephritis for 32.24% and minimal lesion for 24.28% in 407 patients with IgAN.Lee′s classification was correlated to the intensity of IgA deposition（Z=17.187,P〈0.05）.Conclusion The pathological characteristics of IgAN are varied.There is a correlation between Lee′s classification and the intensity of IgA deposition in IgAN.