PTEN和Livin在肾透明细胞癌中的表达及临床意义

Expression and clinical significance of PTEN and Livin in clear cell renal carcinoma

目的探讨PTEN及Livin在肾透明细胞癌中表达的意义及两者的相互关系。方法应用免疫组化SP法检测50例肾透明细胞癌、25例癌旁组织(距肿瘤边缘>1cm)及10例正常肾组织中PTEN及Livin的表达。并对两者与组织学分级、淋巴结转移和临床分期等生物学行为间的关系进行分析。结果 PTEN在肾透明细胞癌中的阳性表达率明显低于癌旁及正常肾组织,差异有统计学意义(P<0.01);Livin在正常肾组织及癌旁组织中无表达,而在肾透明细胞癌中高表达,差异有统计学意义(P<0.01)。在不同临床分期的肾透明细胞癌组织中PTEN和Livin的表达有显著差异性(P<0.01);并且两个因子的表达呈显著负相关(rS=-0.395,P<0.01)。结论 PTEN,Livin在肾透明细胞癌的发生发展中起重要的作用,两个因子联合检测可为肾透明细胞癌的预后评估提供重要依据。

Objective To study the expression of VFEN, Livin in human clear cell renal carcinoma （RC- CC） and to investigate their relationship. Methods We detected the expression of PTEN and Livin in 50 cases of RCCC tissues, 25 eases of adjacent tissues and 10 cases of normal renal tissues by using immunohistochemistrical SP method, and analyzed the relationship between the expression and the biological behavior, such as histological grade, lymph node metastases and clinical staging. Results The positive rate of PTEN in RCCC tissues was significant lower than that in renal tissue adjacent to carcinoma and normal renal tissues, had statistical significance（P 〈0.01 ）. Livin in renal tissues adjacent to carcinoma and normal renal tissues didnt express, while in RCCC, it was high expression, with statistical significance（P 〈0.01 ）. In RCCC, with the increasing of the clinical stage, the positive rate of FInN gradually decreased but the Liviu gradually increased, with statistical significance（P 〈0.01 ）. The expression of VFEN and Livin were negatively correlated（ r = -0.395, P 〈 0.01 ）. Conclusions PTEN and Livin may play an important role in the development of RCCC. Combined detection of these two factors can be used as prognostic evaluation of RCCC.