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5-HT相关基因与自杀的研究进展 被引量：2

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摘要 本文对5-HT相关基因与自杀行为的关联的研究进展做一综述。
作者 白红 袁国桢 王兴 张玉琦
机构地区 皖南医学院 无锡精神卫生中心
出处 《国际精神病学杂志》 2012年第1期27-30,共4页 Journal Of International Psychiatry
基金 无锡市医学技术重大项目基金资助(YGZX1116)
关键词 自杀 5-HT 基因
分类号 C913.9 [经济管理]
  • 相关文献

参考文献13

  • 1Hawton K, Van Heeringen K. Suicide. Lancet. 2009; 373: 1372 - 1381.
  • 2Zill P, Btittner A, Eisenmenger W, et al. Predominant expres- sion of tryptophan hydroxylase 1 mRNA in the pituitary: a postmortem study in human brain. Neuroscience, 2009 ; 159 : 1274 - 1282.
  • 3Stefulj J. Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide. Psychiatry Res. (2010), doi : 10. 1016/j. psychres. 2010 ;034 : 1.
  • 4Perroud N, Neidhart E, Petit B, et al. Simultaneous analysis of serotonin transporter, tryptophan hydroxylase 1 and 2 gene expression in the ventral prefrontal cortex of suicide victims. Am J Med Genet B Neuropsychiatr Genet. 2010 ; 153B :909 - 918.
  • 5Lopez VA, Detera - Wadleigh S, Cardona I, et al. Nested association between cenetic variation in trptophan hydroxylase II, bipolar affective disorer, and suicide attempts. Biol Psychiatry,2006 ;23 : 165 - 168.
  • 6De Luea V, Hlorsek D, Likhodi O, et al. The interaction between TP2 promoter haplotypes and clinical demographic risk factors in suicide victims with major psychoses. Genes Brain Behav. 2006 ;5 ( 1 ) : 107 - 110.
  • 7艾明,况利,陈建梅,李大奇,高新学,黎雪梅.5-羟色胺转运体基因第二内含子多态性与自杀未遂的关联分析[J].中国行为医学科学,2007,16(12):1078-1079. 被引量：4
  • 8艾明,况利,李大奇,陈建梅,高新学,黎雪梅.5-羟色胺转运体基因多态性与自杀未遂的关联研究[J].中国神经精神疾病杂志,2007,33(11):685-686. 被引量：4
  • 9Li D, He L. Meta - analysis supports association between serotonin transporter (5 - HTT) and suicidal behavior. Mol Psychiatry,2007 ; 12:47 - 54.
  • 10Kia- Keating BM, Glatt SJ, Tsuang MT. Meta- analyses suggest association between COMT, but not HTR1 B, alleles,and suicidal behavior. Am J Med Genet B Neuropsychiatr Genet. 2007 ; 144B: 1048 - 1053.

二级参考文献35

  • 1李华芳,林治光,王慧芳,潘令仪,庄冬梅,姚培芬,顾牛范.自杀行为患者血小板5-HT浓度[J].上海精神医学,2003,15(1):1-3. 被引量：9
  • 2潘令仪,王祖承.自杀的国内研究概况[J].中国行为医学科学,2005,14(7):669-670. 被引量：39
  • 3Brent D A, Bridge J, Johnson B A, et al. Suicidal behavior runs in families: a controlled family study of adolescent suicide victims[J]. Arch Gen Psychiatry, 1996, 53(12): 1145.
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  • 5Warren J T, Peacock M L, Rodriguez L C, et al. An MspI polymorphism in the human serotonin receptor gene (HTR2): detection by DGGE and RFLP analysis[J]. Hum Mol Genet, 1993, 2(3): 338.
  • 6Zhang H Y, Ishigaki T, Chen K, et al. Serotonin 2A receptor gene polymorphism in mood disorders[J]. Biol Psychiatry, 1997, 41(7): 768.
  • 7Correa H, Duval F, Mokrani M L, et al. Serotonergic function and suicidal behavior in schizophrenia[J]. Schizophr Res, 2002, 56(1～2): 75.
  • 8Arias B, Gasto C, Catalan R, et al. The 5-HT2A receptor gene 102T/C polymorphism is associated with suicidal behavior in depressed patient[J]. Am J Med Genet(Neuropsychiatr Genet), 2001, 105(8): 801.
  • 9Bonnier B, Gorwood P, Hamon M, et al. Association of 5-HT2A receptor gene polymorphism with major affective disorders: the case of a subgroup of bipolar disorder with low suicide risk[J]. Biol Psychiatry, 2002, 51(9): 762.
  • 10Turecki G, Briere R, Dewar K, et al. Prediction of level of serotonin 2A receptor binding by serotonin receptor 2A genetic variation in postmortem brain samples from subjects who did or did not commit suicide[J]. Am J Psychiatry, 1999, 156(4): 1456.

共引文献7

同被引文献43

  • 1虎晓岷,尹晓涛,王家同.自杀未遂者自杀行为的心理社会影响因素的病例对照研究[J].第四军医大学学报,2005,26(16):1523-1525. 被引量：14
  • 2Bertolote JM,Fleischmann A.A global perspective in the epidemiology of suicide[J].Suicidology,2002,7(2):6-8.
  • 3Phillips MR,Li X,Zhang Y.Suicide rates in China,1995-99[J].Lancet,2002,359(9309):835-840.
  • 4Souery D,Van Gestel S,Massat I,et al.Tryptophan hydroxylase polymorphism and suicidality in unipolar and bipolar affective disorders:a multicenter association study[J].Biological Psychiatry,2001,49(5):405-409.
  • 5Stefulj J,Kubat M,Balija M,et al.TPH gene polymorphism and aging:indication of combined effect on the predisposition to violent suicide[J].American Journal of Medical Genetics Part B:Neuropsychiatric Genetics,2006,141B(2):139-141.
  • 6Wilson ST,Stanley B,Brent DA,et al.The tryptophan hydroxylase-1 A218C polymorphism is associated with diagnosis,but not suicidal behavior,in borderline personality disorder[J].American Journal of Medical Genetics Part B:Neuropsychiatric Genetics,2009,150B(2):202-208.
  • 7Saetre P,Lundmark P,Wang A,et al.The Tryptophan hydroxylase 1(TPH1) gene,schizophrenia susceptibility,and suicidal behavior:a multi-centre case-control study and meta-analysis[J].American Journal of Medical Genetics,Part B:Neuropsychiatric Genetics,2010,153(2):387-396.
  • 8Brezo J,Bureau A,Merette C,et al.Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders:a 22-year longitudinal gene-environment study[J].Molecular Psychiatry,2010,15(8):831-843.
  • 9Perez-Rodriguze MM,Weinstein S,New AS,et al.Tryptophan-hydroxylase 2 haplotype association with borderline personality disorder and aggression in a sample of patients with personality disorders and healthy controls[J].Journal of Psychiatric Research,2010,44(15):1075-1081.
  • 10Fudalej S,Ilgen M,Fudalej M,et al.Association between tryptophan hydroxylase 2 gene polymorphism and completed suicide[J].Suicide and Life-Threatening Behavior,2010,40(6):553-560.

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国际精神病学杂志
2012年 第1期

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