埃索美拉唑等联合治疗消化性溃疡的临床观察

Clinical observation of Esomeprazole in treating peptic ulcer

目的 评价埃索美拉唑、阿莫西林、克拉霉素联合治疗消化性溃疡的临床疗效.方法将符合条件的143例患者随机分为A组（埃索美拉唑、阿莫西林、克拉霉素）和B组（奥美拉唑、阿莫西林、克拉霉素）,治疗1周后,A组以埃索美拉唑20 mg Bid,B组以奥美拉唑20 mg Bid维持治疗6周~7周.3个月后复查胃镜及14C-尿素呼气试验,观察2组溃疡愈合率及幽门螺杆菌（Hp）根治率.结果 A组和B组Hp根治率分别为92.59%和87.10%,2组比较无统计学差异（P〉0.05）.A组和B组溃疡愈合率分别为93.83%和90.23%,疼痛缓解率在3 d内A组明显高于B组,7 d后2组无显著差异.结论埃索美拉唑三联疗法能有效地清除幽门螺杆菌及提高溃疡愈合率,是一种可根治、有高效、副作用少的治疗方案,值得临床推广应用.

Objective To study the effeet of esomeprazole and omeprazole triple therapy on peptic ulcer.Methods The patients with peptic ulcer were divided randomly into esomeprazole triple therapy group （A group）and omeprazole triple therapy guoup （B group）.After the treatment was used for 1 weeks,gastroscopy and Helicobacterpriori were reexamined. Healing rate of peptic ulcer and eradication rate of were observed in two groups. Results The rate of ulcer cicatrization of group A and group B were 93.83% （76/81）and 90.23% （56/62）,respectively. Two of them had no statistical difference. Eradication rate of in group A and group B was 92.59% （75/81 ） 和 87.10% （54/62）,respectively. It had no statistical difference （P〉0.05）.The pain relieving rate of two group had diference in 3 days,A gruop higher relieving rate than B group. But two groups had no diference after 7 days. Conclusion Esomeprazole triple therapy for Helicobacter pylori can effectively remove Helicobacter pylori and improve ulcer healing rate, can be a radical, a highly efficient, less side-effects of treatment, it was worthy of clinical application.