从环磷酸腺苷通路研究氯胺酮对学习记忆的影响

From cyclic AMP pathway to research the ketamine-related learning and memory

背景大量的研究表明，环磷酸腺苷反应元件结合蛋白（cAMP response element binding protein，CREB）直接或间接激活相关基因转录，在学习记忆等方面发挥重要作用。另外，研究证实受环磷酸腺苷（cyclicAMP，cAMP）调节的下游蛋白CREB参与了氯胺酮导致未成年大鼠学习记忆障碍的形成。目的研究氯胺酮与cAMP通路及相关调控蛋白细胞外调节激酶（extracellular signal regulating kinase，ERK）对学习记忆的影响。内容cAMP激活蛋白激酶A（protein kinaseA，PKA）磷酸化并激活CREB，后者是一种重要的核蛋白，其调节启动子中具有环磷酸腺苷反应单元（cAMP response element，CRE）的基因转录，这种核转录因子具有调节包括学习记忆在内的广泛的生物学功能。趋向希望从cAMP通路和ERK通路中，摸索一条治疗氯胺酮导致的学习记忆障碍的新途径。

Background Studies have shown that cAMP response element binding protein （CREB） plays an important role in learning and memorization by activating relevant gene transcription directly or indirectly. In addition, CREB which is downstream protein regulated by cyclic AMP （cAMP） involves in the learning and memory deficits caused by ketamine in minor rats. Objective To discuss the effect of ketamine, cAMP pathway and relevant regulate protein extracellular signal regulating kinase （ERK） on learning and memory. Content It has been shown that cAMP alters the phosphorylation state of protein kinase A （PKA） and activation of CREB, the latter is an important nuclear protein, its regulating promoter involves in genetic transcription of cAMP response element （CRE）, which has many biological functions including regulation of learning and memory. Trend To explore a new method for treatment of learning and memory deficits induced by ketamine from cAMP and ERK signaling pathway.