血管活性肠肽与某些胃肠动力紊乱性疾病的内在关联研究进展

The Research Progress of Pathogenic Relationship between Vasoactive Intestinal Peptide and Some Gastric Motility Disorders

血管活性肠肽(VIP)是广泛分布于全身各器官系统中的一种舒血管因子和神经递质。目前的研究证明,VIP与许多临床疾病的发生、发展、转归、治疗及预后关系密切,阐明其机制对疾病临床表现的把握和治疗用药的遴选有重要价值。本文将VIP的分布和作用尤其与胃食管反流病、贲门失弛缓症、糖尿病胃肠动力障碍、功能性消化不良、慢性肝病、急性胰腺炎、肠易激综合征、便秘等胃肠动力紊乱性疾病内在关联研究进展进行综述。

Vasoactive intestinal peptide（VIP） is a kind of potent vasodilator and neurotransmitter which spreads in all organs.Current researches have proved that VIP is closely related to the incidence,development,treatment and prognosis of many diseases.It is important to clarify its mechanism in order to fully understand the clinical features of these diseases as well as correctly choose treatment and medicines.This article will summarize the research progress on distribution and effect of VIP,especially its internal connections with gastroesophageal reflux disease,achalasia,disorders of gastrointestinal motility in diabetes,functional dyspepsia,chronic liver disease,acute pancreatitis,irritable bowel syndrome,constipation and gastrointestinal motility disorders.