Calcium channel blockers and Alzheimer's disease 被引量：2

Calcium channel blockers and Alzheimer’s disease

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摘要 Alzheimer＇s disease is characterized by two pathological hallmarks： amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer＇s disease. Calcium channel blockers are effective therapeutics for treating Alzheimer＇s disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer＇s disease theraov. Alzheimer＇s disease is characterized by two pathological hallmarks： amyloid plaques and neurofibrillary tangles. In addition, calcium homeostasis is disrupted in the course of human aging Recent research shows that dense plaques can cause functional alteration of calcium signals in mice with Alzheimer＇s disease. Calcium channel blockers are effective therapeutics for treating Alzheimer＇s disease. This review provides an overview of the current research of calcium channel blockers involved in Alzheimer＇s disease theraov.

作者 Yi Tan Yulin Deng Hong Qing

机构地区 School of Life Science

出处《Neural Regeneration Research》 SCIE CAS CSCD 2012年第2期137-140,共4页 中国神经再生研究（英文版）

基金 supported by the National Natural Science Foundation of China, No. 81171206

关键词 Alzheimer＇s disease caic-ium channel calcium homeostasis Alzheimer＇s diseasepathogenesis Β-AMYLOID calcium channel blocker Alzheimer＇s disease caic-ium channel calcium homeostasis Alzheimer＇s diseasepathogenesis β-amyloid calcium channel blocker

分类号 Q421 [生物学—神经生物学] N1 [自然科学总论]

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Calcium channel blockers and Alzheimer's disease 被引量：2

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