摘要
Although Parkinson＇s disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson＇s disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson＇s disease to highlight the possibility of Parkinson＇s disease treatment strategies that incorporate autophagy-lysosome pathway modulation.
Although Parkinson＇s disease is the most common neurodegenerative movement disorder, the mechanisms of pathogenesis remain poorly understood. Recent findings have shown that deregulation of the autophagy-lysosome pathway is involved in the pathogenesis of Parkinson＇s disease. This review summarizes the most recent findings and discusses the unique role of the autophagy-lysosome pathway in Parkinson＇s disease to highlight the possibility of Parkinson＇s disease treatment strategies that incorporate autophagy-lysosome pathway modulation.
基金
sponsored by the National Natural Science Foundation of China, No. 81100941
a Grant of Leading Scientist and Innovation Team in the Science and Technology Development Foundation of Jilin Province, No. 20111805
a Youth Grant in the Science and Technology Development Foundation of Jilin Province, No. 20090174
