DNA免疫吸附柱治疗狼疮性肾炎的临床应用

Clinical Application of DNA Immunoadsorbent on Treating Lupus Nephritis

目的:观察DNA免疫吸附柱对狼疮性肾炎患者的临床疗效。方法:选择16例活动性狼疮性肾炎患者,采用DNA免疫吸附柱进行32例次血液吸附。观察相关症状及蛋白尿改善情况:ANA、ds-DNA清除效果;血常规、肝、肾功能、电解质、免疫球蛋白等影响程度。结果:吸附后症状明显改善,尿蛋白减轻;ANA水平显著下降(P=0.0001),ds-DNA抗体完全清除;血中有形成份、肝、肾功能、电解质等无明显影响。结论:DNA免疫吸附的净化疗法是治疗狼疮性肾炎特异性相对较强、疗效好、无明显毒副反应的一种新疗法。

Objective： To evaluate the clinical effect of DNA immunoadsorbent for hemoperfusion on systemic, lupus crythematosus nephritis. Methods： Sixteen active lupus nephritis patients were enrolled and treated by hemoperfusion with DNA immunoadsorbent. The symptoms, skin damage and proteinuria were observed. The levels of anti-nuclear antibody and anti-dsDNA antibody were tested to observe the effect of immunoadsorbent. Renal function, hepatic function, electrolyte, immunoglobulin and blood cells were monitored to evaluate the biocompatibility. Results： There were significant amelioration of symptoms, skin damage and poteinuria. The levels of anti-nuclear antibody were decreased significantly（P=0.000 1）, Anti-ds DNA antibodys were removed completely. There were no significant change of renal function, hepatic function, electrolyte, immunoglobulin and blood ceils. Conclusions： Hemoperfusion with DNA immunoadsorbent was an effective and specific new technique to treat lupus nephritis. Little adverse reaction will make it more widely applied in clinical practice.