摘要
从药用地不容(Stephania officinarum Lo et Yang)的块根中分得8种生物碱,根据其理化性质、波谱分析及化学方法鉴定为异紫堇定碱(Ⅰ),1-四氢巴马汀碱(Ⅱ)、青风藤碱(Ⅲ)、克班宁(Ⅳ)、异波尔定碱(Ⅴ)、紫堇块茎碱(Ⅵ)、巴马汀碱(Ⅶ)和 N-β-甲基四氢巴马汀碱硝酸盐(Ⅷ)。其中Ⅰ为主要生物碱,得率为1.24%。Ⅷ为天然界中新的季铵型生物碱,并首次证实以硝酸盐形式存在于植物体中。
Eight alkaloids have been isolated from the roots of Stephania officinarum Lo et Yang, which is a novel species growing in Gengma district of Yunnan province.The structures of these compounds were identified as isocorydine (Ⅰ),1-tetrahydropalmatine (Ⅱ),sinoacuti- ne (Ⅲ),crebanine (Ⅳ),isoboldine (Ⅴ),corytuberine (Ⅵ),palmatine (Ⅶ) and 1-N-β-methyltetrahydropalmatine nitrate (Ⅷ) by spectral and chemical methods.One of them,compound Ⅷ is a new natural quaternary alkaloid.It is the first time that we find compound Ⅷ occurring in nitrate form in the plant.Isocorydine is a main alkaloid with 1.24% yield.
基金
国家自然科学基金
关键词
药用地不容
生物碱
Stephania officinarum Lo et Yang
Alkaloids
I-N-β-methyltetrahydro-palmatine nitrate
