哌拉西林复合制剂致药物热的临床表现

Clinical characteristics of drug fever related to piperacillin compound preparation treatment

目的了解哌拉西林复合制剂致药物热的临床表现,为临床准确诊断药物热提供参考。方法对2007-2010年我院收集的47例哌拉西林复合制剂致发热患者的用药天数、累积用药剂量和实验室检查变化进行统计分析。结果哌拉西林复合制剂导致药物热可伴有嗜酸性粒细胞增加,其致药物热发生的高峰期约在用药后8～14 d,大多数患者发生药物热时哌拉西林的累积用药剂量为1.6～2.7 g.kg-1。结论嗜酸性粒细胞的变化作为诊断药物热的参考依据,药物热的发生与用药时间、累积用药剂量具有一定的相关性。

AIM To understand clinical characteristics of drug fever caused by peperacillin compound preparation and provide the basic information for diagnosis of patients with drug fever. METHODS In this study, 47 hospitalized patients who had drug fever during anti-infective treatment between 2007 and 2010 were enrolled. RESULTS Eosinophile granulocyte increased for most patients who had drug induced fever. Most of drag induced fever was devel- oped between 8 and 14 d after medication treatment and the accumulated medication dosage between 1.6 g kg- 1 and 2.7 g kg- 1. CONCLUSION The change of eosinophile granulocyte could provide the information of drug induced fever di- agnosis and the occurrence of drag fever has correlation with the course of treatment and the accumulated medication dosage.