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地特胰岛素联合阿卡波糖对糖尿病患者脂联素和胰岛素抵抗的影响 被引量：10

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摘要 目的:探讨地特胰岛素联合阿卡波糖对2型糖尿病患者脂联素(APN)水平及胰岛素抵抗(IR)的影响。方法:初次诊断的2型糖尿病患者80例随机分为治疗组和对照组,每组40例。对照组口服阿卡波糖片+二甲双胍片治疗;治疗组口服阿卡波糖片+皮下注射地特胰岛素注射液。观察两组患者血浆A.PN、胰岛素抵抗指数(HOMA-IR)的变化。结果:治疗后治疗组HOMA-IR明显低于对照组(P<0.05),外周血APN水平明显高于对照组(P<0.05)。治疗组血糖达标率为100%,对照组仅为77.5%,两组比较,差异有统计学意义(P<0.05);治疗组平均血糖达标时间为(8.12±1.60)d,对照组为(16.80±3.06)d,两组差异亦有统计学意义(P<0.05)。结论:患者在口服降糖药基础上皮下注射地特胰岛素,可显著提高血浆APN水平,改善患者IR现象,有助于提高临床血糖达标率,缩短血糖达标时间。.
作者 徐月爱 王美娟 王军委 叶先青
机构地区 天台人民医院 温州医学院附属第五医院
出处 《中国药师》 CAS 2012年第1期94-96,共3页 China Pharmacist
关键词 地特胰岛素 2型糖尿病 脂联素 胰岛素抵抗
分类号 R977.15 [医药卫生—药品]
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参考文献7

二级参考文献41

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共引文献97

同被引文献90

  • 1庞家莲,蒙光义,王冬晓.地特胰岛素治疗2型糖尿病临床应用和疗效研究进展[J].医学信息（医学与计算机应用）,2014,0(7):527-529. 被引量：1
  • 2陈秀林.地特胰岛素联合格列美脲对肥胖2型糖尿病患者胰岛素抵抗的影响[J].实用老年医学,2013,27(1):85-87. 被引量：6
  • 3王淑平,赵秀云.地特胰岛素联合阿卡波糖治疗血糖控制不佳的2型糖尿病患者的疗效[J].中国老年学杂志,2014,34(1):243-244. 被引量：9
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引证文献10

二级引证文献58

中国药师
2012年 第1期

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