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Refining Animal Models to Enhance Animal Welfare

Refining Animal Models to Enhance Animal Welfare
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摘要 The use of animals in research will be necessary for scientific advances in the basic and biomedical sciences for the foreseeable future.As we learn more about the ability of animals to experience pain,suffering,and distress,and particularly for mammals,it becomes the responsibility of scientists,institutions,animal caregivers,and veterinarians to seek ways to improve the lives of research animals and refine their care and use.Refinement is one of the three R's emphasized by Russell and Burch,and refers to modification of procedures to minimise the potential for pain,suffering and distress.It may also refer to procedures used to enhance animal comfort.This paper summarizes considerations for refinements in research animal. The use of animals in research will be necessary for scientific advances in the basic and biomedical sciences for the foreseeable future.As we learn more about the ability of animals to experience pain,suffering,and distress,and particularly for mammals,it becomes the responsibility of scientists,institutions,animal caregivers,and veterinarians to seek ways to improve the lives of research animals and refine their care and use.Refinement is one of the three R＇s emphasized by Russell and Burch,and refers to modification of procedures to minimise the potential for pain,suffering and distress.It may also refer to procedures used to enhance animal comfort.This paper summarizes considerations for refinements in research animal.
作者 Patricia V.Turner
机构地区 Dept of Pathobiology
出处 《中国比较医学杂志》 CAS 2012年第1期1-4,共4页 Chinese Journal of Comparative Medicine
关键词 呼吸生理 呼吸道感染 临床分析 症状 Animal welfare Humane endpoints Pilot studies Analgesics care and use
分类号 R332 [医药卫生—人体生理学]
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参考文献7

  • 1Chapman CR, Tuckett RP, Song CW. 2008. Pain and stress in a systems perspective: reciprocal neural, endocrine, and immune interactions. J Pain. 9 (2) : 122 - 45. ( Available free online at : http://www, ncbi. nlm. nih. gov/pmc/articles/PMC2278005/ pdf/nihms-40524, pdf).
  • 2Russell W, Burch R. 1959. The Principles of Humane Experimental Technique. (Full text available free online at: http ://altweb. jhsph, edu/pubs/books/humane_exp/het-toc).
  • 3Schoeb TR, McConnell EE, Juliana MM, Davis JK, Davidson MK, Lindsey JR. 2009. Mycoplasma pulmonis and lymphoma in bioassays in rats. Vet Pathol. 46 (5) :952 - 9. ( Available free online at: http ://vet. sagepub, com/content/46/5/952, long).
  • 4PV Turner, C Pekow, MA Vasbinder, T Brabb. 2011a. Administration of Substances to Laboratory Animals. Part B: Equipment Considerations, Vehicle and Excipient Selection, and Solute Preparation. JAALAS( in press, Sept 2011 ).
  • 5PV Turner, T Brabb, C Pekow, MA Vasbinder. 20lib. Administration of Substances to Laboratory Animals. Part A: Routes of Administration and Factors to Consider. JAALAS ( in press, Sept 2011 ).
  • 6World Organisation for Animal Health [ OIE ], Animal Welfare Mandate of the OIE. Resolution No. XIV adopted by the International Committee of the OlE,Paris, France, 2002.
  • 7World Organization for Animal Health [ OIE ]. Terrestrial Code, Chapter 7.8 : Use of Animals in Research and Education. Paris, France, 2010. http://web, oie. int/eng/normes/mcode/en_ chapitre_l. 7.8. htm.
中国比较医学杂志
2012年 第1期

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