2型糖尿病患者微量白蛋白尿与心血管危险因素的相关性

Correlation of microalbuminuria with cardiovascular risk in type 2 diabetic patients

目的探讨2型糖尿病(T2DM)患者微量白蛋白尿(MAU)与心血管危险因素的相关性。方法 T2DM患者483例,根据尿白蛋白与肌酐比值(ACR)分为正常白蛋白尿组(A组,248例,ACR<30mg/g)和MAU组(B组,235例,ACR 30-300mg/g)。检测两组血清甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、糖化血红蛋白(HbA1c)、空腹血糖(FBG)、餐后2-h血糖(PBG)、空腹胰岛素(FIns)。结果与A组比较,B组TG、TC、LDL-C、FBG、PBG、FIns均明显增加(P<0.05);高血压病、冠心病、动脉粥样硬化的发病率升高(P<0.05)。体重指数、收缩压、TC、FBG是发生MAU的独立危险因素。结论 T2DM患者MAU易合并超重、高血压、糖脂代谢紊乱,心血管疾病风险增加。

Objective To evaluate the correlation of microalbuminuria（MAU） with cardiovascular risks in patients with type 2 diabetes mellitus（T2DM）.Methods On the basis of the ratio of urine albumin to criatinine（ACR）,483 T2DM patients were assigned to two groups of A（248 cases,ACR30 mg/g） and B（235 cases,ACR 30-300 mg/g）.Serum total cholesterol（TC）,triglyceride（TG）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C）,glycolated hemoglobin（HbA1c）,fasting blood glucose（FBG）,postprandial blood glucose（PBG）,fasting insulin（FIns） were detected and compared.Results Serum TG,TC,LDL-C,FBG,PBG and FIns were significantly higher in group B than those in group A（P0.05）.The incidence rates of hypertension,coronary heart disease and atherosclerosis were higher in group B than those in group A（P0.05）.BMI,SBP,TC,FBG were the independent risk factors for MAU.ConclusionT2DM patients with MAU often have obesity,hypertension,hyperglycemia,lipid disorders and increased risks for cardiovascular diseases.