从病毒性心肌炎演变为扩张型心肌病:病毒的作用

From viral myocarditis to developing dilated cardiomyopathy: role of virus

病毒感染、宿主免疫反应、以及遗传和环境变化是决定病毒性心肌炎向扩张型心肌病演变的重要因素,其中病毒感染既是启动又是影响疾病发生发展的关键环节。近年研究发现,病毒不仅对心肌细胞有直接和间接损伤作用,而且还通过逃逸宿主先天免疫、诱导免疫因子分泌或表达异常等机制推动疾病进程。抗病毒治疗有益于病毒性心肌炎患者的恢复,在一定程度上抑制扩张型心肌病的发生。

Viral infection,host immune responses,and genetic or environment changes are the determinant factors for the development from viral myocarditis（VMC）to dilated cardiomyopathy（DCM）,and among them,viral infection is very critical because it initiates and also is involved in the disease process.Recently,some studies found that viruses can not only injure myocardial cells by direct or indirect pathways,but also accelerate the progression of VMC to DCM by evading innate immunity,inducing abnormal immune factors secretion or expression,and other mechanisms.Antiviral therapy is beneficial for VMC patients and it can inhibit the occurrence of DCM to some extent.