乳腺浸润性小叶癌的研究进展

Progress in the Invasive Lobular Carcinoma of the Breast

乳腺浸润性小叶癌是一种较常见的乳腺癌类型,通常表现出显著的形态学、分子特征、以及独特的临床行为,其发生率也在逐年递增,近年来对小叶癌变异型的认识亦逐步加深同时基于对乳腺癌基因特征的研究,发现除了E-cadherin基因外,其他基因也表现出差异性表达本文综述了乳腺浸润性小叶癌的临床病理学特征以及分子病理学等方面的最新研究进展。

Invasive or infiltrative lobular carcinoma （ILC） of the breast is a common type of breast cancer with distinctive morphology, molecular features, and peculiar clinical manifestations. The morbidity of the disease progressively increases annually. Over the past years, the variants of ILC gradually gained recognition. Moreover, based on the studies on the features of the breast cancer gene, differential expression of other genes were found in addition to the E-cadherin gene. The progress in the studies on the clinicopathologic features and molecular pathology oflLC of the breast was reviewed in this article.