提高钾离子浓度抑制心脏中的螺旋波和时空混沌

Suppression of Spiral Waves and Spatiotemporal Chaos in Cardiac Tissue by Elevating Potassium Ion Concentration

采用心脏模型研究了心脏中的螺旋波和时空混沌的抑制。提出了两种抑制策略,一是让细胞外的钾离子浓度突然提高,当提高幅度较大时,该方法能有效抑制心脏中的螺旋波和时空混沌,尤其对被缺陷钉扎的螺旋波也能实现抑制;二是让细胞外的钾离子浓度周期变化,但限制变化的幅度。研究表明,适当选取控制参数,该方法能有效抑制螺旋波和时空混沌,但不能抑制被缺陷钉扎的螺旋波。对控制机制进行了分析。

The suppression of spiral waves and spatiotemporal chaos in cardiac ti ssue was studied based on cardiac model.We proposed two strategies of suppressi ng spiral wave and spatiotemporal chaos.One was to elevate the extracellular po tassium ion concentration suddenly.This method can effectively suppress spiral waves and spatiotemporal chaos when the elevated extracellular potassium ion con centration reaches a critical value,especially when the spiral wave pinned to d efects also can be suppressed.The other was to let the extracellular potassium ion concentration varies periodically while the amplitude of concentration was l imited.We found that the method could effectively suppress spiral waves and spa tiotemporal chaos when the related parameters were properly chosen.But it can n ot suppress the pinned spiral waves.And the control mechanism is discussed in t his paper.