疏血通对慢性肺心病急性加重患者红细胞膜黏弹特性的影响

The Influence Shuxuetong on the Membrane Viscoelasticity of Erythrocyte Taken from Patients with Chronic Pulmonary Heart Disease

探讨疏血通对慢性肺心病急性加重期患者红细胞膜黏弹特性的影响。采用微管吸吮技术,定量测定了慢性肺源性心脏病患者体外使用疏血通前后红细胞膜的黏弹特性的变化情况。结果表明:一定浓度疏血通可降低红细胞膜的弹性模量、黏性系数。这为临床上在肺心病的综合治疗中包括改善红细胞变形性的药物或措施提供了实验依据。

The present paper was aimed to explore the effect of Shuxuetong on the membrane viscoelasticity of erythrocyte taken from the acute phase patients suffering from chronic pulmonary heart disease.The membrane viscoelasticity of erythrocyte was taken from the acute phase patients suffering from chronic pulmonary heart disease.The changes of membrane viscoelasticity of erythrocyte after treated with shuxuetong were detected by micropipette aspiration technique.The results showed that the Shuxuetong of certain concentration could cause the decrease of membrane elastic modulus and viscous coefficients in acute phase patients suffering from chronic pulmonary heart disease.The study offers experimental evidences that the comprehensive treatment of pulmonary heart disease should involve the drug or measure to improve the erythrocyte deformability.