健康志愿者SPECT多巴胺转运体分子影像分析

Single photon emission computed tomography molecular imaging of dopaminetransporter in healthy volunteers

目的研究健康志愿者SPECT多巴胺转运体(DAT)分子影像阅片基础,为分析异常影像提供参考。方法对31名健康志愿者行DAT特异性放射性配体99mTc-TRODAT-1SPECT显像,从解剖标志、放射性分布及对称性等方面,以视觉定性分析DAT影像特征,结合解剖图谱和MRI绘制DAT典型横断层面对应的线条图。结果 26名双侧纹状体横断层面呈典型"熊猫眼"形态,双侧尾状核和壳核大致等大,DAT放射性分布均匀、对称;5名双侧纹状体表现为哑铃形;24名双侧杏仁体显影,呈圆点状;6名丘脑轻度显影。所有志愿者均未见明显非特异性分布。结论健康志愿者SPECT脑DAT分子影像的各组织结构清晰可辨,特异性强。

Objective To study the reading standards of SPECT molecular imaging of dopamine transporter（DAT） in healthy volunteers,in order to provide reference for analysis of abnormal images.Methods A total of 31 healthy volunteers were enrolled.SPECT scan with DAT specific radioligand 99mTc-TRODAT-1 was performed.Then the characteristics of DAT images from anatomical landmark,radioactive distribution and symmetry were quantitatively analyzed,and the line graph corresponding to the typical transverse section of DAT images was also drawn combined with anatomical atlas and MR images.Results The transverse section of bilateral corpora striatum of 26 healthy volunteers showed typical ＂panda eyes＂ pattern,bilateral caudate nucleus and putamen were almost equal,and the radioactive distribution of DAT was uniform and symmetrical,while of the other 5 showed ＂dumbbell shape＂ pattern.A total of 24 healthy volunteers showed round-punctiform bilateral amygdaloid nucleus.There were 6 healthy volunteers whose thalami were visible.No obvious non-specific distribution was observed.Conclusion All organizational structures of SPECT molecular imaging of cerebral DAT in healthy volunteers are clear and readable with high specificity.