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细胞间黏附分子-1异常表达与肝癌的侵袭生长和转移 被引量：10

Abnormal expression of intercellular adhesion molecule-1 and characteristics of invasive growth and metastasis in hepatocelinlar carcinoma
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摘要 肝细胞性肝癌（HCC）的侵袭生长和转移是治疗失败和死亡的主要原因。HCC转移的发生是多步骤、复杂的生物学过程，在体内受到多种因素调节。通常认为HCC转移的过程是原发部位的癌细胞脱离原发病灶进入血流，在远端的转移部位附着于内皮细胞后开始生长，破坏基底膜完整性，形成浸润性生长。
作者 杨君伶 姚登福
机构地区 南通大学附属医院临床医学研究中心
出处 《中华肝脏病杂志》 CAS CSCD 北大核心 2012年第2期158-160,共3页 Chinese Journal of Hepatology
基金 基金项目：南通市社会发展项目（$2010039）
关键词 癌 肝细胞 肿瘤转移 预后 细胞问 黏附分子-1 Carcinoma, hepatocellular Neoplasm metastasis Prognosis Intercellular adhesion molecule-1
分类号 R735.7 [医药卫生—肿瘤]
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参考文献20

  • 1Kikkawa Y,Sudo R,Kon J,et al.Laminin alpha 5 mediates ectopic adhesion of hepatocellular carcinoma through integrins and/or Lutheran/basal cell adhesion molecule.Exp Cell Res,2008,314:2579-2590.
  • 2Wu Y,Qiao X,Qiao S,et al.Targeting integrins in hepatocellular carcinoma.Expert Opin Ther Targets,2011,15:421-437.
  • 3Weber GF,Bjerke MA,DeSimone DW.Integrins and cadherins join forces to form adhesive networks.J Cell Sci,2011,124 Pt 8:1183-1193.
  • 4Raskopf E,Gerceker S,Vogt A,et al.Plasminogen fragment KI-3inhibits expression of adhesion molecules and experimental HCC recurrence in the liver.Int J Colorectal Dis,2009,24:837-844.
  • 5Yang J,Gu Y,Huang X,et al.Dynamic changes of ICAM-1expression in peripheral nervous system following sciatic nerve injury.Neurol Res,2011,33:75-83.
  • 6Shen A,Yang J,Gu Y,et al.Lipopolysaccharide-evoked activation of p38 and JNK leads to an increase in ICAM-1 expression in Schwarm cells of sciatic nerves.FEBS J,2008,275:4343-4353.
  • 7Hayes SH,Seigel GM.Immunoreactivity of ICAM-1 in human tumors,metastases and normal tissues.Int J Clin Exp Pathol,2009,2:553-560.
  • 8Liang S,Slattery M J,Wagner D,et al.Hydrodynamic shear rate regulates melanoma-leukocyte aggregation,melanoma adhesion to the endothelium,and subsequent extravasation.Ann Biomed Eng,2008,36:661-671.
  • 9Verly RM,Rodrigues MA,Daghastanli KR,et al.Effect of cholesterol on the interaction of the amphibian antimicrobial peptide DD K with liposomes.Peptides,2008,29:15-24.
  • 10Park JS,Kim KM,Kim MH,et al.Resveratrol inhibits tumor cell adhesion to endothelial cells by blocking ICAM-1 expression.Anticancer Res,2009,29:355-362.

二级参考文献11

  • 1Reeves HL, Friedman SL. Activation of hepatic stellate cells--a key issue in liver fibrosis. Front Biosci, 2002, 7: d808-826.
  • 2Mann DA, Smart DE. Transcriptional regulation of hepatic stellate cell activation. Gut, 2002, 50: 891-896.
  • 3Zhao FJ, Zhang SL, Ma L, et al. Efficacy of c-erbB-2 antisense oligonucleotide transfeetion on uterine endometrial cancer HEC-1A cell lines. Eur J Gynaecol Oncol, 2007, 28: 263-269.
  • 4Neurath MF, Pettersson S, Meyer zum Biischenfelde KH, et al. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimen- tal colitis in mice. Nat Med, 1996, 2: 998-1004.
  • 5Autieri MV, Yue TL, Ferstein GZ, et al. Antisense oligonucleotides to the p65 subunit of NF-kB inhibit human vascular smooth muscle cell adherence and proliferation and prevent neointima formation in rat carotid arteries. Biochem Biophys Res Commun, 1995, 213: 827- 836.
  • 6Friedman SL. Molecular mechanisms of hepatic fibrosis and principles of therapy. J Gastroenterol, 1997, 32: 424-430.
  • 7Schwabe RF, Bataller R, Brenner DA. Human hepatic steUate cells express CCR5 and RANTES to induce proliferation and migration. Am J Physiol Gastrointest Liver Physiol, 2003, 285: G949-958.
  • 8Gressner AM, Weiskirchen R, Breitkopf K, et al. Roles of TGF-beta in hepatic fibrosis. Front Biosci, 2002, 7: d793-807.
  • 9Mirza A, Liu SL, Frizell E, et al. A role for tissue transglutaminase in hepatic injury and fibrogenesis, and its regulation by NF-kappaB. Am J Physiol, 1997, 272(2 Pt 1): G281-288.
  • 10Schwabe RF, Schnabl B, Kweon YO, et al. CD40 activates NF kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. J Immunol, 2001, 166: 6812-6819.

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中华肝脏病杂志
2012年 第2期

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