鹿瓜多肽注射液对强直性脊柱炎患者血清Vaspin的影响

Effects of Lugua Polypeptide Injection on Serum Vaspin Levels in the Patients of Ankylosing Spondylitis

目的:观察鹿瓜多肽注射液对强直性脊柱炎(AS)患者血清内脏脂肪组织来源的丝氨酸蛋白酶抑制剂(visceraladipose tissue-derived serine protease inhibitor,Vaspin)水平的影响,阐明Vaspin在强直性脊柱炎发生过程中可能的作用机制。方法:采用酶联免疫法测定AS患者鹿瓜多肽注射液治疗前后血清Vaspin水平及炎症因子浓度,并分析血清Vaspin水平与炎症因子间的相互关系。结果:AS组血清Vaspin水平明显高于正常对照组(1.79±0.27vs.0.72±0.08μg/L,P<0.01)。AS组患者血清Vaspin水平与TNF-α及BASDAI呈正相关(r=0.454,P<0.05和r=0.328,P<0.01)。TNF-α是影响空腹血清Vaspin水平的独立相关因素。AS组经鹿瓜多肽注射液治疗后ESR、CRP、TNF-α、BAS-DAI及BASFI均显著降低(均P<0.01),血清Vaspin水平也显著降低(1.79±0.27vs.1.26±0.07μg/L,P<0.01)。结论:鹿瓜多肽注射液能有效抑制致炎性细胞因子产生,控制和延缓疾病活动,同时降低血清Vaspin水平。

Objective：To investigate the effects of lugua polypeptide injection on serum levels of visceral adipose tissue-derived serine protease inhibitor（Vaspin） in patients with ankylosing spondylitis（AS） and to clarify the probable mechanism of Vaspin in the happened of AS.Methods： Serum levels of Vaspin and inflammatory cytokines were measured by ELISA method in the patients of AS.The relationship between the levels of serum Vaspin and inflammatory cytokines were analyzed.Results：The fasting serum levels of Vaspin in the patients of AS group were significantly higher than healthy control group（1.79±0.27 vs.0.72±0.08μg/L,P0.01）.And which was positive correlated with the levels of tumor necrosis factor alpha（TNF-α） and the scores of Bath AS Disease Activity Index（BASDAI）（r=0.454,P0.05 and r=0.328,P0.01）.The TNF-α was an independent factor affecting fasting serum levels of Vaspin.The levels of TNF-α,erythrocyte sedimentation（ESR）,and C-reactive protein（CRP） and the scores of BASDAI and Bath AS Functional Index（BASFI） were significantly decreased after lugua polypeptide injection treatment（all P0.01）.Interestingly,the levels of serum Vaspin were also significantly decreased（1.79±0.27 vs.1.26±0.07 μg/L,P0.01）.Conclusions： Lugua polypeptide injections can effectively inhibit the production of inflammatory cytokines,control or delay disease activity,and reduce serum levels of Vaspin.