探讨利托君治疗先兆早产的效果及不良反应

The effects and adverse of reactions in treatment of threatened premature

目的探讨盐酸利托君(安宝)治疗先兆早产的效果及不良反应。方法我院2009年9月～2011年8月收治的108例先兆早产患者随机分为观察组和对照组各54例,观察组给予利托君静脉滴注,对照组给予硫酸镁静脉滴注。观察两组显效时间、保胎成功率及药物不良反应。结果观察组显效时间均值(47.8±4.2)h短于对照组的(68.2±5.7)h,观察组孕龄延长>7d视为保胎成功,保胎成功率为77%,高于对照组的55%;观察组不良反应发生率22.0%,对照组不良反应发生率5.5%;以上差异均有统计学意义(P<0.05)。结论利托君治疗先兆早产疗效好,能够有效抑制宫缩延长孕龄,但其副作用也比较明显,需要注意掌握用药禁忌及注意事项。

Objective To discuss the effect and adverse reaction of ritodrine hydrochloride in the treatment of threatened premature labor. Methods Our hospital in 2009 September - 2011 August, 108 cases of threatened preterm patients were randomly divided into the observation group and the control group with 54 cases in each group, the observation group to ritodrine infusion, the control group was given intravenous magnesium sulphate infusion. Observate the 2 groups of starting time, the success rate of miscarriage and adverse drug reactions. Results The observation group was shorter than the control group on time mean of （47.8±4.2） h,（68.2±5.7） h, the observation group gestational age extend 〉 7d as tocolysis successfully, protecting a success rate of 77%, higher than that of control group 55%, the observation group; the incidence of adverse reactions in 22.0%, control group the incidence of adverse reactions of more than 5.5%; the differences were statis tically significant （P 〈 0.05）. Conclusion Ritodrine in treatment of threatened premature labor with good curative effect, can inhibit contractions extend gestational age, but its side effects are more obvious, need to pay attention to master the medication contraindications and precautions.