阿托伐他汀对新疆维吾尔族急性冠脉综合征患者血清高敏C反应蛋白水平的影响

Effects of Atorvastatin on hs-CRP Levels of Xinjiang Uiygur Patients with Acute Coronary Syndrome

目的探讨不同剂量阿托伐他汀对新疆维吾尔族急性冠脉综合征患者血清高敏C反应蛋白水平(hs-CRP)的影响。方法将89例择期行冠脉介入治疗的维吾尔族急性冠脉综合征患者随机分为阿托伐他汀常规治疗组(对照组,20mg/d,45例)和阿托伐他汀强化治疗组(试验组,40mg/d,44例),观察治疗后4周两组患者血清高敏C反应蛋白水平(hs-CRP)。结果两组患者4周后血清hs-CRP水平均有不同程度下降,且试验组hs-CRP水平显著低于治疗前及对照组同期检测值(P<0.01)。结论阿托伐他汀可明显降低维吾尔族急性冠脉综合征患者血清hs-CRP水平,调脂强度与维吾尔族急性冠脉综合征患者血清hs-CRP浓度的下降趋势相关。

To investigate the effect of different doses of atorvastatin on hs - CRP levels of Xinjiang Uiygur patients suf- fered from acute coronary syndrome. Methods Eighty - nine acute coronary syndrome patients for Uiygur population underwent selected percutaneous coronary intervention（PCI） were enrolled. The patients were divided into two groups at random：45 cases of normal dose group（20mg/d, control group） and 44 cases of study group（40mg/d）. The level of hs - CRP was measured after therapy for 4 weeks. Re- suits After 4 weeks of therapy for the patients in the two groups,the level of hs - CRP was lower than before treatment, whereas the level of hs - CRP in study group was significantly decreased than control group（ P 〈 0.01 ）. Conclusion Atorvastatin could decrase the level of hs - CRP in acute coronary syndrome patients for Uiygur population. The strength of adjusting the fat has correlation with the declining tendency in hs - CRP.