产前血型抗体水平监测与新生儿溶血病相关系数探讨

Correlation Coefficient between the Monitoring of Blood Group Antibody Levels in Pregnant Women and Incidence of Hemolytic Disease of Newborns

目的探讨孕妇IgG血型抗体效价动态检测变化与新生儿溶血病相关系数研究。方法 640例O型RhD阳性孕妇从妊娠16周开始检查IgG抗-A(B)效价,如效价超过64以上,即给予口服茵陈汤加减,每6周或4周复查1次。记录动态检测变化结果,同时跟踪观察。结果 640例O型孕妇末次IgG抗-A(B)效价<64、64、128、256、512和≥1024各组所占比例分别为45.9%、20.6%、18.4%、10.0%、3.7%、1.2%。效价≥64的346例O型孕妇生产190例ABOHDN,其发生率为54.91%。结论 ABOHDN的发生与孕期动态升高的IgG血型抗体效价呈正相关。

To study the correlation coefficient between the dynamic changes of IgG ABO blood type antibody titer of pregnant women and incidence of hemolytic disease of newborns（ HDN）. Methods We initially detected IgG anti - A （B） titer from 16 weeks of pregnancy for 640 pregnant women whose blood group were O RhD - positive, If the titer was more than 64, oral administration of Yin Chert Decoction was needed, and reexamination was taken after every 4 or 6 weeks. Changes in the dynamic test results were recor- ded, and blood group antibody titers during pregnancy were tracking observed. Results In the 640 pregnant women, the last O - IgG anti -A （B） titer was less than 64,64,128,256,512 and more than 1024 respectively. The proportion of each group was 45.9%, 20.6%, 18.4% , 10.0% , 3.7% and 1.2% respectively. In the 346 cases of pregnant women whose titer was more than 64,190 cases of infants caused ABO - HDN,and the rate was 54.91%. Conclusion The correlation between the occurrence of ABO - HDN and dynamically in- creasing IgG antibody titers of blood group was positive.