摘要
An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better.This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost.It was developed from a single-head clinical SPECT scanner,with a seven-pinhole collimator and a four-degree-offreedom motion control stage.Several key techniques were developed,including high-resolution image reconstruction algorithm,high accuracy geometrical calibration method,and optimized system matrix derivation scheme.The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function.Experiments of point source and ultra micro hot rod phantom were conducted.With a spatial resolution of 0.5-0.6 mm,this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system.
An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better. This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost. It was developed from a single-head clinical SPECT scanner, with a seven-pinhole collimator and a four-degree-of- freedom motion control stage. Several key techniques were developed, including high-resolution image reconstruction algorithm, high accuracy geometrical calibration method, and optimized system matrix derivation scheme. The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function. Experiments of point source and ultra micro hot rod phantom were conducted. With a spatial resolution of 0.5-0.6 mm, this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system.
基金
Supported by Specialized Research Fund for the Doctoral Program of Higher Education(SRFDP200800031071)
National Natural Science Foundation of China (No.10975086)
the National High Technology Research and Development Program of China(No.2006AA020802)
