食管鳞状细胞癌FDG PET／CT显像SUVmax与肿瘤增殖、侵袭和血管生成的关系

The correlation between FDG uptake and the expressions of Ki67, MMP-2 and microvessel densityin esophageal carcinoma

目的探讨食管鳞状细胞癌（简称鳞癌）FDGPET／CT显像SUVmax与肿瘤细胞Ki67、基质金属蛋白酶2（MMP-2）和微血管密度（MVD）的相关性，以评估SUVmax是否可作为术前反映肿瘤增殖活性、侵袭性和微血管生成的指标。方法选择术后病理证实的食管鳞癌患者47例，术前1周内行^18F-FDGPET／CT检查；术后对患者肿瘤标本行Ki67、MMP-2和MVD免疫组织化学染色，用Pearson直线相关分析病灶SUVmax与上述指标的相关性。结果47处病灶SUVmax为1．9-4．0，平均为12．504±6．805。免疫组织化学检查：Ki67平均指数为（67．837±29．798）％，MMP-2平均指数为（71．551±27．126）％，MVD平均为（18．429±9．603）个。SUVmax与Ki67指数、MMP-2指数间呈正相关，r值分别为0．581和0．594，P均〈0．05；而SUVmax与MVD之间不具有相关性，r=0．167，P〉0．05。结论SUVmax可反映食管鳞癌肿瘤增殖活性和侵袭性，不能反映肿瘤血管生成。

Objective To investigate the correlation between is F-FDG SUVmax and the expressions of Ki67, matrix metalloproteinase-2 （MMP-2） and microvessel density （MVD） in esophageal carcinoma as to determine if SUVmax might reflect cancer cell proliferation, invasiveness and angiogenesis. Methods From Jan. 2007 to Jan. 2009, 47 patients underwent^18SF-FDG PET/CT one week before surgical resection ofesophageal carcinoma. The tumor specimens were analyzed by immunohistochemical staining for Ki67 prolifer- ation index, MMP-2 marker index and MVD. The correlation between SUVmax over tumor foci on ^18F-FDG PET/CT and Ki67 index, MMP-2 index and MVD was analyzed respectively using Pearson linear correla- tion. Results The mean ^18F-FDG SUVmax, Ki67 index, MMP-2 index and MVD were （ 12. 504 ± 6. 805） （range： 1.9 to 24.0）, （67. 837 ± 29. 798 ） %, （71. 551±27. 126） % and 18. 429 ± 9. 603 respectively. SUVmas positively correlated with Ki67 （r =0. 581, P 〈0.05） and MMP-2 indices （r =0. 594, P 〈 0. 05）, but not correlated with MVD （r = 0. 167, P 〉 0.05）. Conclusion is F-FDG SUVmax may semi- quantitatively reflect the proliferation and invasiveness of esophageal carcinoma, but not tumor angiogenesis.