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腺苷及选择性A2a受体激动剂regadenoson心肌负荷试验 被引量:8

Adenosine and a selective A2a receptor agonist regadenoson used in myocardial stress test
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摘要 腺昔负荷试验心肌灌注显像诊断冠心病的价值已经得到公认,但其不良反应发生率较高。与腺苷相比,选择性A2。受体激动剂,如regadenoson具有独特优势,目前已完成Ⅲ期临床试验,有可能代替腺苷作为新的负荷试验药物。笔者对腺苷及选择性A2。受体激动剂regadenoson心肌负荷试验作一综述。 Adenosine pharmacological myocardial stress test has been widely used in clinic. How- ever, the side effects related with adenosine administration has been an issue of controversy. Current Phase IU study of regadenoson, a selective A2a receptor agonist, reveals its potential to substitute adenosine as a new agent for pharmacological myocardial stress test. This review briefs adenosine and regadenoson and their clinical utilities in myocardial stress test.
出处 《中华核医学与分子影像杂志》 CSCD 北大核心 2012年第1期75-78,共4页 Chinese Journal of Nuclear Medicine and Molecular Imaging
基金 国家科技支撑计划(2007BA105801)
关键词 腺苷 REGADENOSON 心肌缺血 放射性核素显像 Adenosine Regadenoson Myocardial ischemia Radionuclide imaging
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  • 1Miyamoto MI, Vernotico SL, Majmundar H, et al. Pharmacologic stress myocardial perfusion imaging: a practical approach. J Nucl Cardiol, 2007, 14: 250-255.
  • 2Bours MJ, Swennen El, Di Virgilio F, et al. Adenosine 5'-triphos- phate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther, 2006, 112: 358-404.
  • 3[ Salcedo J, Kern MJ. Effects of caffeine and theophylline on coro- nary hyperemia induced by adenosine or dipyridamole. Catheter Cardiovasc Interv, 2009, 74: 598-605.
  • 4何作祥.药物负荷试验心肌灌注显像[J].中华心血管病杂志,2008,36(11):1054-1056. 被引量:1
  • 5Verani MS, Mahmarion JJ, Hixson JB, et al. Diagnosis of coronaryartery disease by controlled coronary vasodilation with adenosine and 20t TI scintigraphy in patients unable to exercise. Circulation, 1990, 82 : 80-87.
  • 6Gupta NC, Esterbrooks DJ, Hilleman DE, et al. Comparison of aden- osine and exercise 201 T1 single-photon emision computed tomography (SPECT) myocardial perfusion imaging. The GE SPECT Multi- center Adenosine Study Group. J Am Coil Cardiol, 1992, 19 : 248- 257.
  • 7Kapur A, Latus KA, Davies G, et al. A comparison of three radionu- clide myocardial perfusion tracers in clinical practice:the ROBUST study. Eur J Nucl Med Imaging, 2002, 29 : 1608-1616.
  • 8Nguyen T,Heo J,Ogilby JD,et al. Single photon emission computed tomography with 201 T1 during adenosine-induced coronary hyperemia: correlation with coronary artefiography, exercise thallium imaging and two-dimensional echocardiography. J Am Coil Cardiol, 1990, 16 : 1375-1383.
  • 9Nishimura S, Mahmarian JJ, Boyce TM, et al. Quantitative 201T1 sin- gle-photon emission computed tomography during maximal pharma- cologic coronary vasodilation with adenosine for assessing coronary artery disease. J Am Coil Cardiol, 1991,18: 736-745.
  • 10田月琴,王金城,何作祥,王蒨,胡奉环,杨伟宪,王琦,戴皓洁,姚稚明.腺苷负荷试验心肌灌注显像诊断冠心病的临床价值[J].中华心血管病杂志,2005,33(1):58-61. 被引量:81

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