四种药用地衣的化学成分

CHEMICAL CONSTITUENTS OF FOUR MEDICINAL LICHENS

从四种药用地衣中分离鉴定了黑茶渍素(1),降斑点酸(2),8′-乙氧基-降斑点酸(3),(—)-placodiolic acid(4),松萝酸(5),珠光酸(6),伏勒米醇(7)和五个相应的单芳环衍生物:β-苔黑酚酸甲酯(8),赤星衣酸(9),赤星衣酸乙酯(10)。2-羟基-4-甲氧基-6-正戊基苯甲酸(11)和2,4-二羟基6-正戊基苯甲酸(12)等12个化合物。其中金丝带[Le-thariella zahlbruckneri(DR.)]中含1,4,8,和10金丝刷[Lethariella cladonioids(Nyl·)Krog.Syn.]中含1,2,3,8和9,雀石蕊[Cladonia stellaris(Opiz.)Pouzar & Vezda]中含1,5,6,11和12黑石耳[Dermatocarpon miniatum(L.)Mann.]中含7,4被鉴定为前人报道的桔黄色素(canarionic acid)。

In the continuing search for exploitation and utilization of lichens,we have isolated 12 com- pounds from 4 species of medicinal lichens used in the North-western China.Their structures were deduced from spectral and chemical evidence,and the constituents are as follows: 1.Lethariella zahlbruckneri (DR.)Krog,atranorin (1),ethyl haematommate (10),methyl β-orcinolcarboxylate (8),(-)-placodiolic acid (4).2.Lethariella cladonioids (Nyl.) Krog. Syn.,methyl β-orcinolcarboxylate (8),haematommic acid (9),atranorin (1),norstictic acid (2), 8'-O-ethylnorstictic acid (3).3.Cladonia stellaris (Opiz.) Pouzar & Vezda,(+)-usnic acid (5), perlatolic acid (6),atranorin (1),2,4-dihydroxy-6-n-pentylbenzoic acid (12),2-hydroxy-4-meth- yoxy-6-n-pentylbenzoic acid (11).4.Dermatocarpon miniatum (L.) Mann.,D-volemitol. A colour substance canarionic acid reported previously occuring in the genus Lethariella was proved to be identical with (-)-placodiolic acid.