12岁以下儿童EB病毒感染的血清流行病学调查

Seroepidemiological study of epstein-barr virus infection in children under 12 years old

目的：了解12岁以下儿童EB病毒（Epstein-barr virus,EBV）感染现状及流行病学特点。方法：收集2010年重庆儿童医院539份0~12岁儿童的血清标本,采用ELISA法,对每份血清进行EBVCA-IgG及EBVCA-IgM检测,根据检测结果判断血清标本是否存在EBV感染。Excel软件储存数据,运用统计学分析软件SPSS17.0进行统计分析。结果：重庆地区12岁以下儿童EBV新发感染率为9.7%,累计感染率为51.2%。0岁~、0.5岁~、1岁~、3岁~及6~12岁新发感染率分别为20.0%、8.2%、12.4%、4.9%、7.0%;累计感染率分别为70.9%（由于胎传抗体的影响,实际感染率低于该值）、17.6%、33.1%、57.4%、71.6%。结论：重庆地区12岁以下儿童EBV的感染率低于目前公认的我国3~5岁儿童的感染率（90%）;也低于2006年北京地区3岁以下儿童的感染率（71%）,但仍高于经济发达的西方国家,EBV感染的高峰年龄段在学龄前期。

Objective:To understand epstein-barr virus(EBV) infection status and epidemiological characteristics in children under 12 years old in Chongqing.Methods:539 serum samples of healthy children of 0~12 years old were collected from the Children's Hospital of Chongqing Medical University.EBVCA-IgG and EBVCA-IgM in each sample were tested by ELISA.The database was established with Excel and statistical analysis was performed with software SPSS17.0.Results:The cumulative infection rate of EBV in children between 0~12 years old was 51.2% and recent infection rate was 9.7%.The recent infection rate of EBV in 0 year~,0.5 year~,1 year~,3 years~ and 6~12 years group was 20%,8.2%,12.4%,4.9% and 7.0%,respectively.The cumulative infection rate in 0 year~,0.5 year~,1 years~,3 years~ and 6~12 years group was 70.9%,17.6%,33.1%,57.4% and 71.6%,respectively.Conclusion:EBV infection rate in children under 12 years in Chongqing is lower than 90%,the currently reported rate of EBV infection in children between 3~5 years old in China,and also lower than that in children under 3 years old in Beijing in 2006.However,it is still above the rate in western economically developed countries.Pre-school age is the peak period for EBV infection.