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股骨头坏死病因发病机制的研究进展 被引量:15

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摘要 股骨头坏死(osteonecrosis of the femoralhead,ONFH)指由多种病因造成股骨头血液循环中断或受损,导致骨细胞、骨髓造血细胞、脂肪细胞等股骨头骨的有活力成分的不同程度地死亡,并且坏死与修复同时进行,股骨头坏死区的力学强度逐渐下降,继而引起股骨头塌陷[1],最终发展为严重的骨性关节炎嘲,患髋出现疼痛、功能障碍等症状。
出处 《实用临床医学(江西)》 CAS 2011年第11期132-134,138,共4页 Practical Clinical Medicine
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  • 3Wang Y,Yin L,Li Y,et al. Preventive effects of puerarin on alcohol- induced osteonecrosis [J]. Clin Orthop Relat Res, 2008,466 : 1059 - 1067.
  • 4Yeh CH,Chang JK,Wang YH,et al. Ethanol may suppress wnt/β - catenin signaling on human bone marrow stroma cells [J]. Clinical Orthopaedics and Related Research ,2008,466 : 1047 - 1053.
  • 5Glueck CJ,Freiberg RA,Oghene J,et al. Association between the T- 786C eNOS polymorphism and idiopathic osteonecrosis of the head of the femur[J]. J Bone Joint Surg(Am) ,2007,89:2460 -2468.
  • 6Kyung Hoi Koo, JSLYJLK JKJJYHJK. Endothelial nitrie oxide synthase gene polymorphisms in patients with nontraumatic femoral head osteonecrosis[J]. 2006,1722 - 1728.
  • 7Kim TH, Hong JM,Lee JY,et al. Promoter polymorphisms of the vascular endothelial growth factor gene is associated with an osteonecrosis of the femoral head in the Korean population [ J ]. Osteoarthritis Cartilage ,2008,16:287 - 291.
  • 8Bjorkman A,Svensson PJ, Hillarp A,et al. Factor V leiden and prothrombin genemutation: risk factors for osteonecrosis of the femoral head in adults [ J ]. Clin Orthop Relat Res,2004,168 - 172.
  • 9Ficat RP. Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment[ J]. J Bone Joint Surg(Br) , 1985,3 - 9.
  • 10Wai Man Tang,KYC. Avascular necrosis of femoral head: a short review[ J]. 2006,98 - 101.

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