头颈部非霍奇金淋巴瘤临床特征和治疗及预后因素分析

Analysis on clinical characteristics,treatments and prognostic factors of head and neck non-Hodgkin's lymphoma

目的:探讨原发于头颈部的非霍奇金淋巴瘤(NHL)的临床特征、治疗和预后影响因素。方法:回顾性分析107例头颈部NHL患者的临床资料。结果:本研究样本的中位年龄为54岁;最常见的原发部位为扁桃体29例(27.10%),其次为鼻腔28例(26.17%);最常见的组织学类型为弥漫性大B细胞淋巴瘤46例(42.99%),其次为NK/T淋巴瘤24例(22.43%)。化疗联合应用美罗华可以有效提高生存率;IPI和组织学类型是影响预后的危险因素,且IPI是比组织学类型影响更强的危险因素。结论:原发于头颈部的NHL是一种常见的恶性疾病,其在发病年龄、原发部位、组织学类型、治疗方法和影响预后的因素存在一定特征。

Objective： To study the clinical characteristics, treatments and prognoses of the primary non Hodgkin＇s lymphoma（NHL）in head and neck. Method：Clinical manifestations and clinicopathology characteristics of 107 NHL patients in head and neck were analyzed retrospectively. Result：The median age of patients with head and neck NHL was 54 years. The most commonly primary site was tonsil （29 cases,27.10%）,and the secondly primary site was nasal cavity （28 cases, 26. 17 ~）. The most common histologic subtype was diffuse large B cell lymphoma（46 cases, 42.99 ~ ）, and the secondly one was NK/T cell lymphoma（24 cases, 22.43 ~ ）. We found that the combination of rituximab was superior than that of chemotherapy alone. Prognosis depended on both IPI and histological subtype, and IPI was a more dangerous factor than histological subtype. Conclusion：The primary NHL is a common neoplasm in the head and neck region. Characteristic in age, primary site, histologic subtype, treat ment and prognostic factors were helpful to understand and treat nonHodgkin＇s lymphoma in head and neck.