帕宁方治疗帕金森病的临床研究

Clinical research on Parkinson's disease treated by Paning Decoction

目的:观察帕宁方治疗帕金森病(PD)的临床疗效。方法:将81例患者随机分成治疗组和对照组,对照组给予美多巴治疗,治疗组加服帕宁方,每日一剂,水煎,分2次服,疗程均为12周。观察两组临床疗效及治疗前后的帕金森病改良的统一评分量表(UPDRS)评分、改良的Hoehn﹠Yahr(H-Y)分级情况、美多巴使用量及不良反应。结果:治疗组的UPDRS评分、临床疗效明显优于对照组(P<0.05),两组的H-Y分级和美多巴使用量无显著性差异(P>0.05),治疗组2例出现恶心、胃肠胀气,无其他不良反应。结论:联合帕宁方治疗可以明显改善PD患者症状,增强效疗,提高生活质量。

Objective：To observe the clinical efficacy of Paning decoction for Parkinson＇s disease（PD）.Methods：Eighty-one patients were randomly assigned to the treated group and the control group.The patients in control group were treated with Madopar,and the treated group was administered with paning decoction additionally,a daily agent,water decoction,taking 2 times.The duration of treatment was 12 weeks.The clinical efficacy,the Unified Parkinson Disease Rating Scale（UPDRS）,H﹠Y grade assessment,Madopar dosage and adverse reactions were observed before and after treatment.Results：The UPDRS score and the clinical efficacy of the treated group were obviously better than those of the control group（P0.05）.The H﹠Y grade assessment and the Madopar dosage had no significant statistical difference（P0.05）.During the treatment,two patients felt mild nausea and flatulence（take up 5.0%）,and no other adverse reactions appeared.Conclusion：The treatment can improve symptoms and live quality of PD patients.