3-氮杂-A-homo-4a-雄烯-4-酮化合物的合成及体外抗肿瘤活性研究

Synthesis and Antitumor Activities of 3-aza-A-homo-4a-androstene-4-one

当在甾体化合物中引入氮原子或含氮官能团后,所得化合物的生物活性会明显提高。用酮经过酯化、肟化、重排、水解等反应合成3-氮杂-A-homo-4a-雄烯-4-酮化合物,并用六种人体肿瘤细胞珠对所合成化合物进行体外抗肿瘤活性的研究。

The introduction of heteroatom or the replacement of one or more carbon atoms in steroidal molecule by a heteroatom will affect the chemical properties of the steroidal molecule and often result in alteration of its biological activity.3-aza-A-homo-4a-androstene-4-one were synthesized and the antiactivities of the compounds were studied.