过氧化物酶增殖物激活受体γ在间质性肺疾病中的作用

The Effect of Peroxisome Proliferators Activated Receptor γ on Interstitial Lung Disease

过氧化物酶增殖物激活受体γ(PPARγ)是配体激活的核激素受体,以往只认识到其在脂肪生成、代谢及维持内环境稳态的作用。近年来的体内外实验使研究者逐渐认识到过氧化物酶增殖物激活受体在抗炎、调节细胞增殖、分化、凋亡及抗纤维化中均起到重要作用。特别是PPARγ在间质性肺疾病中的负性调节作用逐渐受到重视,期待进一步对PPARγ抗纤维化作用的研究,使其成为治疗肺纤维化的新靶点。

Peroxisome proliferators activated receptor γ（PPARγ）is a nuclear hormone receptor activated by ligand.It has been realized that PPARγ played an important role in the lipogenesis,metabolism and homeostasis.The research work of recent years enabled scientists to understand that PPAR are important in anti-inflammatory,modulating cell proliferation and differentiation,apoptosis and anti-fibrosis processes.In particular,the down-regulation effect of PPARγ on the interstitial lung disease attracted the researcher＇s attention.Further research on PPARγ in interstitial lung disease is needed to clarify whether it can be a good therapeutic target of pulmonary fibrosis.