阿加曲班治疗急性缺血性脑卒中疗效及应用时机的临床研究

Clinical research of Argatroban in treating acute ischemic stroke in different phase

目的观察急性缺血性脑卒中后不同时间段应用阿加曲班的临床疗效。方法随机选取我院发病24h内的急性缺血性脑卒中患者80例,根据发病6～12h和13～24h 2个时间段应用阿加曲班,将患者分为A组28例,B组52例。7d后进行美国国立卫生研究院脑卒中量表(NIHSS)评分,以判定临床疗效。结果与治疗前比较,2组治疗后NIHSS评分明显降低,差异有统计学意义(P<0.05)。2组临床疗效比较差异无统计学意义(P>0.05)。结论阿加曲班治疗急性缺血性脑卒中有临床疗效。发病24h内不同时间应用对临床疗效无影响。

Objective To compare the clinical efficacy of Argatroban in treating acute ischemic stroke in different phase. Methods 80 patients with acute ischemic stroke were recruited and ana- lyzed randomly within 48 hours of onset. First,intravenous Argatroban was observed for 7 days after the NIHSS score. The patients were divided into A group（6-12 h,n=28） ,B group（13--24 h, n= 52）. NIHSS scores were compared between test and control groups after the treatment for 7 days. Results There were statistically significant difference between pre- and post-treatment within the each group,P〈0.05. The difference was not statistically significant between A and B group,P〉0.05. Conclusion Argatroban could improve the prognosis of patients with acute ischemic stroke and there is no effect on clinical efficacy using Argatroban in different phase within 24 h onset of acute ischemic stroke.