慢性肾脏疾病与甲状腺激素的相关性研究

目的探讨慢性肾脏疾病与甲状腺激素的相关性。方法对2009年3月至2010年6月胶南市人民医院的485例住院患者,根据内生肌酐清除率(Ccr)分3组,比较各组TSH、FT3和FT4水平的差异,并采用Binary logistic回归分析肾功能对TSH、FT3和FT4的影响。结果 FT3在CCr<25组[(2.97±0.48pomol/L)]要明显低于CCr>50组[(4.32±0.09pomol/L)];FT4和TSH在各组之间无明显差异。lo-gistic回归分析显示Ccr降低是低FT3的危险因素,OR=0.968,P<0.001。结论慢性肾脏疾病与低T3综合征密切相关。

Objective To investigate the relationship between chronic kidney disease（CKD） and thyroid hormone.Methods A total of 485 hospitalized patients in people＇s hospital of Jiaonan from 2009--3 to 2010--6 were divided to 3groups respectively according to there levels of CCr.Logistic regression analysis was used to estimate the effect of CKD on the levels d TSH,FT3 and FT4.Results The serum level of FT3 in CCr〈25group（2. 97 ±0.48pomol/l） was lower than that of the CCr〉50 group （4.32± 0.09pomol/l）; Logistic regression revealed that decreased CCr were risk factors for low serum FT3 .Conclusion low T3 syndrome is closely related to chronic kidney disease.