地佐辛与吗啡用于老年妇科术后静脉镇痛效应的比较

Comparison of dezocine and morphine in patient-controlled intravenous analgesia after old gynecologic operation

目的比较地佐辛与吗啡用于术后老年妇科患者自控镇痛(PCIA)的效应及安全性。方法 60例择期行开腹子宫切除术的患者,随机分为2组,每组30例,分别接受D组:地佐辛0.6mg/kg+托烷司琼0.1mg/kg加生理盐水至100mL:M组:吗啡0.8mg/kg+托烷司琼0.1mg/kg加生理盐水至100mL行PCIA治疗,分别记录术后4、8、12、24、48hVAS疼痛评分及Ramsay镇静、不良反应发生情况,记录PCA有效按压次数,患者总体满意度等。结果 2组患者术后各时间点VAS评分和Ramsay镇静评分比较,差异无统计学意义(P>0.05),D组镇痛总体满意度明显高于M组(P<0.05),D组不良反应的发生率明显低于M组(P<0.05)。结论与吗啡相比,地佐辛用于老年妇科手术术后镇痛同样能提供满意效果,且不良反应发生率低。

Objective To compare the analgesic efficacy and safety of dzocine and morphine in patient-controlled intravenous analgesia（PCIA）after senile gynecologic operation.Methods Sixty patients underwent elective hysterectomy were randomly divided into two groups with 30 cases each. Groups D（nm30）：Dezocine 0.6mg/kg ＋ tropistron 0.1mg/kg -t- sodium chloride to 100mL.Groups M（n=30）：morphine 0.8mg/kg ＋ tropistron 0.1mg/kg ＋ sodium chloride to 100 mL.The postoperative analgesic visual analogue scale and sedation scale at 4,8,12,24 and 48 h were recorded.The effective PCA boluses,side effects as well as patients satisfactory degree were recorded and compared. Results In the two groups of patients at different time points,VAS scores and the Ramsay scores had no statistically gnificant difference （P〉0.05）.the overall patient satisfaction of group D were significantly higher than that of group M（P〈0.05）,The prevalence of side effects in group D was significantly lower than that in groups M.Conclusion Compared with morphine,PCIA with dezocine may provide a satisfactory postoperative analgesia with less side effects.